D-alanine 2-hydroxymethyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydrofolate + D-alanine + H₂O tetrahydrofolate + 2-methylserine

The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, D-alanine, and H₂O, whereas its two products are tetrahydrofolate and 2-methylserine.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase. This enzyme is also called 2-methylserine hydroxymethyltransferase. This enzyme participates in one carbon pool by folate.

[edit] References

• IUBMB entry for 2.1.2.7
• BRENDA references for 2.1.2.7 (Recommended.)
• PubMed references for 2.1.2.7
• PubMed Central references for 2.1.2.7
• Google Scholar references for 2.1.2.7
• Wilson EM and Snell EE (1962). "Metabolism of alpha-methylserine. I. alpha-Methylserine hydroxymethyltransferase". J. Biol. Chem. 237: 3171–3179. 

[edit] External links

The CAS registry number for this enzyme class is 9075-76-7.

• IUBMB entry for 2.1.2.7

• KEGG entry for 2.1.2.7

• BRENDA entry for 2.1.2.7

• NiceZyme view of 2.1.2.7

• EC2PDB: PDB structures for 2.1.2.7

• PRIAM entry for 2.1.2.7

• PUMA2 entry for 2.1.2.7

• IntEnz: Integrated Enzyme entry for 2.1.2.7

• MetaCyc entry for 2.1.2.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050413: D-alanine 2-hydroxymethyltransferase

• AMIGO entry for GO code 0050413: D-alanine 2-hydroxymethyltransferase