D-alanine-poly(phosphoribitol) ligase

From Wikipedia, the free encyclopedia

In enzymology, a D-alanine-poly(phosphoribitol) ligase (EC 6.1.1.13) is an enzyme that catalyzes the chemical reaction

ATP + D-alanine + poly(ribitol phosphate) AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)

The 3 substrates of this enzyme are ATP, D-alanine, and poly(ribitol phosphate), whereas its 3 products are AMP, diphosphate, and O-D-alanyl-poly(ribitol phosphate).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is D-alanine:poly(phosphoribitol) ligase (AMP-forming). Other names in common use include D-alanyl-poly(phosphoribitol) synthetase, D-alanine: membrane acceptor ligase, D-alanine-D-alanyl carrier protein ligase, D-alanine-membrane acceptor ligase, and D-alanine-activating enzyme. This enzyme participates in d-alanine metabolism.

[edit] References

• IUBMB entry for 6.1.1.13
• BRENDA references for 6.1.1.13 (Recommended.)
• PubMed references for 6.1.1.13
• PubMed Central references for 6.1.1.13
• Google Scholar references for 6.1.1.13
• BADDILEY J, NEUHAUS FC (1960). "The enzymic activation of D-alanine". Biochem. J. 75: 579–87. PMID 13795638. 
• Reusch VM Jr, Neuhaus FC (1971). "D-Alanine: membrane acceptor ligase from Lactobacillus casei". J. Biol. Chem. 246: 6136–43. PMID 4399593. 
• Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W (1995). "Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation". J. Biol. Chem. 270: 15598–606. PMID 7797557. 
• Heaton MP, Neuhaus FC (1994). "Role of the D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid". J. Bacteriol. 176: 681–90. PMID 8300523. 
• Debabov DV, Heaton MP, Zhang Q, Stewart KD, Lambalot RH, Neuhaus FC (1996). "The D-Alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC". J. Bacteriol. 178: 3869–76. PMID 8682792. 

[edit] External links

The CAS registry number for this enzyme class is 9023-65-8.

• IUBMB entry for 6.1.1.13

• KEGG entry for 6.1.1.13

• BRENDA entry for 6.1.1.13

• NiceZyme view of 6.1.1.13

• EC2PDB: PDB structures for 6.1.1.13

• PRIAM entry for 6.1.1.13

• PUMA2 entry for 6.1.1.13

• IntEnz: Integrated Enzyme entry for 6.1.1.13

• MetaCyc entry for 6.1.1.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047473: D-alanine-poly(phosphoribitol) ligase

• AMIGO entry for GO code 0047473: D-alanine-poly(phosphoribitol) ligase