D-alanine-alanyl-poly(glycerolphosphate) ligase

From Wikipedia, the free encyclopedia

In enzymology, a D-alanine-alanyl-poly(glycerolphosphate) ligase (EC 6.3.2.16) is an enzyme that catalyzes the chemical reaction

ATP + D-alanine + alanyl-poly(glycerolphosphate) ADP + phosphate + D-alanyl-alanyl-poly(glycerolphosphate)

The 3 substrates of this enzyme are ATP, D-alanine, and alanyl-poly(glycerolphosphate), whereas its 3 products are ADP, phosphate, and D-alanyl-alanyl-poly(glycerolphosphate).

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming). Other names in common use include D-alanyl-alanyl-poly(glycerolphosphate) synthetase, D-alanine:membrane-acceptor ligase, D-alanylalanylpoly(phosphoglycerol) synthetase, D-alanyl-poly(phosphoglycerol) synthetase, and D-alanine-membrane acceptor-ligase. This enzyme participates in d-alanine metabolism.

[edit] References

• IUBMB entry for 6.3.2.16
• BRENDA references for 6.3.2.16 (Recommended.)
• PubMed references for 6.3.2.16
• PubMed Central references for 6.3.2.16
• Google Scholar references for 6.3.2.16
• Reusch VM Jr, Neuhaus FC (1971). "D-Alanine: membrane acceptor ligase from Lactobacillus casei". J. Biol. Chem. 246: 6136–43. PMID 4399593. 

[edit] External links

The CAS registry number for this enzyme class is 9046-58-6.

• IUBMB entry for 6.3.2.16

• KEGG entry for 6.3.2.16

• BRENDA entry for 6.3.2.16

• NiceZyme view of 6.3.2.16

• EC2PDB: PDB structures for 6.3.2.16

• PRIAM entry for 6.3.2.16

• PUMA2 entry for 6.3.2.16

• IntEnz: Integrated Enzyme entry for 6.3.2.16

• MetaCyc entry for 6.3.2.16

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047481: D-alanine-alanyl-poly(glycerolphosphate) ligase

• AMIGO entry for GO code 0047481: D-alanine-alanyl-poly(glycerolphosphate) ligase