D-2-hydroxy-acid dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) is an enzyme that catalyzes the chemical reaction

(R)-lactate + acceptor pyruvate + reduced acceptor

Thus, the two substrates of this enzyme are (R)-lactate and acceptor, whereas its two products are pyruvate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (R)-2-hydroxy-acid:acceptor 2-oxidoreductase. Other names in common use include D-2-hydroxy acid dehydrogenase, and (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase. It has 2 cofactors: FAD, and Zinc.

[edit] References

• IUBMB entry for 1.1.99.6
• BRENDA references for 1.1.99.6 (Recommended.)
• PubMed references for 1.1.99.6
• PubMed Central references for 1.1.99.6
• Google Scholar references for 1.1.99.6
• GREGOLIN C, SINGER TP, KEARNEY EB, BOERI E (1961). "The formation and enzymatic properties of the various lactic dehydrogenases of yeast". Ann. N. Y. Acad. Sci. 94: 780–97. PMID 13901630. 
• Nygaard AP (1961). "D(-)-Lactate cytochrome c reductase, a flavoprotein from yeast". J. Biol. Chem. 236: 920–925. 
• Tubbs PK and Greville GD (1959). "Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria". Biochim. Biophys. Acta 34: 290–291. 

[edit] External links

The CAS registry number for this enzyme class is 9028-83-5.

• IUBMB entry for 1.1.99.6

• KEGG entry for 1.1.99.6

• BRENDA entry for 1.1.99.6

• NiceZyme view of 1.1.99.6

• EC2PDB: PDB structures for 1.1.99.6

• PRIAM entry for 1.1.99.6

• PUMA2 entry for 1.1.99.6

• IntEnz: Integrated Enzyme entry for 1.1.99.6

• MetaCyc entry for 1.1.99.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047809: D-2-hydroxy-acid dehydrogenase

• AMIGO entry for GO code 0047809: D-2-hydroxy-acid dehydrogenase