Cytosine deaminase

From Wikipedia, the free encyclopedia

In enzymology, a cytosine deaminase (EC 3.5.4.1) is an enzyme that catalyzes the chemical reaction

cytosine + H₂O uracil + NH₃

Thus, the two substrates of this enzyme are cytosine and H₂O, whereas its two products are uracil and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytosine aminohydrolase. This enzyme is also called isocytosine deaminase. This enzyme participates in pyrimidine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1K6W, 1K70, 1OX7, 1P6O, 1R9X, 1R9Y, 1RA0, 1RA5, 1RAK, 1RB7, 1UAQ, 1YSB, and 1YSD.

[edit] References

• IUBMB entry for 3.5.4.1
• BRENDA references for 3.5.4.1 (Recommended.)
• PubMed references for 3.5.4.1
• PubMed Central references for 3.5.4.1
• Google Scholar references for 3.5.4.1
• COHEN SS, BARNER HD (1957). "The conversion of 5-methyldeoxycytidine to thymidine in vitro and in vivo". J. Biol. Chem. 226: 631–42. PMID 13438848. 
• Kream J and Chargaff E (1952). "On the cytosine deaminase of yeast". J. Am. Chem. Soc. 74: 5157–5160. doi:10.1021/ja01140a050. 

[edit] External links

The CAS registry number for this enzyme class is 9025-05-2.

• IUBMB entry for 3.5.4.1

• KEGG entry for 3.5.4.1

• BRENDA entry for 3.5.4.1

• NiceZyme view of 3.5.4.1

• EC2PDB: PDB structures for 3.5.4.1

• PRIAM entry for 3.5.4.1

• PUMA2 entry for 3.5.4.1

• IntEnz: Integrated Enzyme entry for 3.5.4.1

• MetaCyc entry for 3.5.4.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004131: cytosine deaminase

• AMIGO entry for GO code 0004131: cytosine deaminase