Cytochrome c oxidase subunit II
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| Bacterial cytochrome c oxidase complex. Subunit II indicated by blue. | ||
| Cytochrome c oxidase subunit II, transmembrane domain | ||
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| Identifiers | ||
| Symbol | COX2_TM | |
| Pfam | PF02790 | |
| InterPro | IPR011759 | |
| PROSITE | PDOC00075 | |
| SCOP | 1occ | |
| TCDB | 3.D.4 | |
| OPM family | 4 | |
| OPM protein | 1v55 | |
| Available PDB structures:
1v54B:2-83 1oczB:1-83 2occB:1-83 1ocrB:1-83 1ocoB:1-83 1v55B:2-83 1occO:1-83 1m57B:35-122 1m56H:35-122 1qleB:41-128 |
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| Cytochrome C oxidase subunit II, periplasmic domain | ||
|---|---|---|
| Identifiers | ||
| Symbol | COX2 | |
| Pfam | PF00116 | |
| InterPro | IPR002429 | |
| PROSITE | PDOC00075 | |
| SCOP | 1occ | |
| TCDB | 3.D.4 | |
| OPM family | 4 | |
| OPM protein | 1v55 | |
| Available PDB structures:
1v54B:95-214 1oczB:95-214 2occB:95-214 1ocrB:95-214 1ocoB:95-214 1v55B:95-214 1occO:95-214 1m57B:134-270 1m56H:134-270 1qleB:141-263 1fftB:129-225 1cyw :129-225 1cyx :129-225 1fwxC:572-648 1qniB:489-579 1ehkB:92-167 2cuaA:59-134 1xmeB:59-134 |
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Cytochrome C oxidase subunit II, transmembrane region is a second subunit of cytochrome c oxidase.
Cytochrome c oxidase (EC 1.9.3.1)[1][2] is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. The enzyme complex consists of 3-4 subunits (prokaryotes) to up to 13 polypeptides (mammals).
Subunit 2 (CO II) transfers the electrons from cytochrome c to the catalytic subunit 1. It contains two adjacent transmembrane regions in its N-terminus and the major part of the protein is exposed to the periplasmic or to the mitochondrial intermembrane space, respectively. CO II provides the substrate-binding site and contains a copper centre called Cu(A) (see IPR001505), probably the primary acceptor in cytochrome c oxidase. An exception is the corresponding subunit of the cbb3-type oxidase which lacks the copper A redox-centre. Several bacterial CO II have a C-terminal extension that contains a covalently bound haem c.
The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices.
[edit] Human proteins containing this domain
COII; COX2; MT-CO2;
[edit] References
- ^ Capaldi RA, Malatesta F, Darley-Usmar VM (1983). "Structure of cytochrome c oxidase". Biochim. Biophys. Acta 726 (2): 135-148. PMID 6307356.
- ^ Rumbley J, Gennis RB, Garcia-Horsman JA, Barquera B, Ma J (1994). "The superfamily of heme-copper respiratory oxidases". J. Bacteriol. 176 (18): 5587-5600. PMID 8083153.
- [1]. The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A. Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S; Science 1996;272:1136-1144. PubMed
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