Cytochrome-c3 hydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a cytochrome-c3 hydrogenase (EC 1.12.2.1) is an enzyme that catalyzes the chemical reaction

2 H₂ + ferricytochrome c₃ $\rightleftharpoons$ 4 H⁺ + ferrocytochrome c₃

Thus, the two substrates of this enzyme are H₂ and ferricytochrome c3, whereas its two products are H⁺ and ferrocytochrome c3.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with a cytochrome as acceptor. The systematic name of this enzyme class is hydrogen:ferricytochrome-c3 oxidoreductase. Other names in common use include H2:ferricytochrome c3 oxidoreductase, cytochrome c3 reductase, cytochrome hydrogenase, and hydrogenase [ambiguous]. It has 3 cofactors: iron, Nickel, and Iron-sulfur.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1FRV, 1H2R, 1UBH, 1UBJ, 1UBK, 1UBL, 1UBM, 1UBO, 1UBR, 1UBT, 1UBU, 1WUH, 1WUI, 1WUJ, 1WUK, 1WUL, 1YQ9, 1YQW, and 1YRQ.

[edit] References

IUBMB entry for 1.12.2.1
BRENDA references for 1.12.2.1 (Recommended.)
PubMed references for 1.12.2.1
PubMed Central references for 1.12.2.1
Google Scholar references for 1.12.2.1
DerVartanian DV and Le Gall J (1974). "A monomolecular electron transfer chain: structure and function of cytochrome c3". Biochim. Biophys. Acta 346: 79–99.
Higuchi Y, Yasuoka N, Kakudo M, Katsube Y, Yagi T, Inokuchi H (1987). "Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F". J. Biol. Chem. 262: 2823–5. PMID 3546297.
Rilkis E and Rittenberg D (1961). "Some observations on the enzyme, hydrogenase". J. Biol. Chem. 236: 2526–2529.
Sadana JC and Morey AV (1961). "Purification and properties of the hydrogenase of Desulfovibrio desulfuricans". Biochim. Biophys. Acta 50: 153–163. doi:10.1016/0006-3002(61)91072-1.
Fontecilla-Camps JC (1995). "Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas". Nature. 373: 580–7. doi:10.1038/373580a0. PMID 7854413.
Fontecilla-Camps JC (1999). "The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center". Structure. 7: 557–66. doi:10.1016/S0969-2126(99)80072-0. PMID 10378275.