Cystine reductase

From Wikipedia, the free encyclopedia

In enzymology, a cystine reductase (EC 1.8.1.6) is an enzyme that catalyzes the chemical reaction

2 L-cysteine + NAD⁺ L-cystine + NADH + H⁺

Thus, the two substrates of this enzyme are L-cysteine and NAD⁺, whereas its 3 products are L-cystine, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-cysteine:NAD+ oxidoreductase. Other names in common use include cystine reductase (NADH), NADH-dependent cystine reductase, cystine reductase (NADH2), and NADH2:L-cystine oxidoreductase. This enzyme participates in cysteine metabolism.

[edit] References

• IUBMB entry for 1.8.1.6
• BRENDA references for 1.8.1.6 (Recommended.)
• PubMed references for 1.8.1.6
• PubMed Central references for 1.8.1.6
• Google Scholar references for 1.8.1.6
• ROMANO AH, NICKERSON WJ (1954). "Cystine reductase of pea seeds and yeasts". J. Biol. Chem. 208: 409–16. PMID 13174550. 
• Carroll JE, Kosicki GW, Thibert RJ (1970). "Alpha-substituted cystines as possible substrates for cystine reductase and L-amino acid oxidase". Biochim. Biophys. Acta. 198: 601–3. PMID 5436160. 
• Maresca B, Jacobson E, Medoff G, Kobayashi G (1978). "Cystine reductase in the dimorphic fungus Histoplasma capsulatum". J. Bacteriol. 135: 987–92. PMID 211119. 

[edit] External links

The CAS registry number for this enzyme class is 9029-18-9.

• IUBMB entry for 1.8.1.6

• KEGG entry for 1.8.1.6

• BRENDA entry for 1.8.1.6

• NiceZyme view of 1.8.1.6

• EC2PDB: PDB structures for 1.8.1.6

• PRIAM entry for 1.8.1.6

• PUMA2 entry for 1.8.1.6

• IntEnz: Integrated Enzyme entry for 1.8.1.6

• MetaCyc entry for 1.8.1.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050456: cystine reductase

• AMIGO entry for GO code 0050456: cystine reductase