Cysteine transaminase

From Wikipedia, the free encyclopedia

In enzymology, a cysteine transaminase (EC 2.6.1.3) is an enzyme that catalyzes the chemical reaction

L-cysteine + 2-oxoglutarate mercaptopyruvate + L-glutamate

Thus, the two substrates of this enzyme are L-cysteine and 2-oxoglutarate, whereas its two products are mercaptopyruvate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-cysteine:2-oxoglutarate aminotransferase. Other names in common use include cysteine aminotransferase, L-cysteine aminotransferase, and CGT. This enzyme participates in cysteine metabolism. It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 2.6.1.3
• BRENDA references for 2.6.1.3 (Recommended.)
• PubMed references for 2.6.1.3
• PubMed Central references for 2.6.1.3
• Google Scholar references for 2.6.1.3
• CHATAGNER F, SAURET-IGNAZI G (Paris). "[Role of transamination and pyridoxal phosphate in the enzymatic formation of hydrogen sulfide from cysteine by the rat liver under anaerobiosis.]". Bull. Soc. Chim. Biol.: 415–28. PMID 13342749. 

[edit] External links

The CAS registry number for this enzyme class is 9030-32-4.

• IUBMB entry for 2.6.1.3

• KEGG entry for 2.6.1.3

• BRENDA entry for 2.6.1.3

• NiceZyme view of 2.6.1.3

• EC2PDB: PDB structures for 2.6.1.3

• PRIAM entry for 2.6.1.3

• PUMA2 entry for 2.6.1.3

• IntEnz: Integrated Enzyme entry for 2.6.1.3

• MetaCyc entry for 2.6.1.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047801: cysteine transaminase

• AMIGO entry for GO code 0047801: cysteine transaminase