Cysteine-tRNA ligase

From Wikipedia, the free encyclopedia

In enzymology, a cysteine-tRNA ligase (EC 6.1.1.16) is an enzyme that catalyzes the chemical reaction

ATP + L-cysteine + tRNACys AMP + diphosphate + L-cysteinyl-tRNACys

The 3 substrates of this enzyme are ATP, L-cysteine, and tRNA(Cys), whereas its 3 products are AMP, diphosphate, and L-cysteinyl-tRNA(Cys).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys ligase (AMP-forming). Other names in common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme participates in cysteine metabolism and aminoacyl-trna biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1LI5, 1LI7, and 1U0B.

[edit] References

• IUBMB entry for 6.1.1.16
• BRENDA references for 6.1.1.16 (Recommended.)
• PubMed references for 6.1.1.16
• PubMed Central references for 6.1.1.16
• Google Scholar references for 6.1.1.16
• McCorquodale DJ (1964). "The separation and partial purification of aminoacyl-RNA synthetases from Escherichia coli". Biochim. Biophys. Acta 91: 541–548. 

[edit] External links

The CAS registry number for this enzyme class is 37318-56-2.

• IUBMB entry for 6.1.1.16

• KEGG entry for 6.1.1.16

• BRENDA entry for 6.1.1.16

• NiceZyme view of 6.1.1.16

• EC2PDB: PDB structures for 6.1.1.16

• PRIAM entry for 6.1.1.16

• PUMA2 entry for 6.1.1.16

• IntEnz: Integrated Enzyme entry for 6.1.1.16

• MetaCyc entry for 6.1.1.16

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004817: cysteine-tRNA ligase

• AMIGO entry for GO code 0004817: cysteine-tRNA ligase