Cysteine-S-conjugate beta-lyase

From Wikipedia, the free encyclopedia

In enzymology, a cysteine-S-conjugate beta-lyase (EC 4.4.1.13) is an enzyme that catalyzes the chemical reaction

RS-CH₂-CH(NH₃+)COO- RSH + NH₃ + pyruvate

Hence, this enzyme has one substrate, RS-CH2-CH(NH3+)COO-, but 3 products: RSH, NH₃, and pyruvate.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming). Other names in common use include cysteine conjugate beta-lyase, glutamine transaminase K/cysteine conjugate beta-lyase, and L-cysteine-S-conjugate thiol-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1W7L, 1W7M, and 1W7N.

[edit] References

• IUBMB entry for 4.4.1.13
• BRENDA references for 4.4.1.13 (Recommended.)
• PubMed references for 4.4.1.13
• PubMed Central references for 4.4.1.13
• Google Scholar references for 4.4.1.13
• Tateishi M, Suzuki S, Shimizu H (1978). "Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs". J. Biol. Chem. 253: 8854–9. PMID 721818. 

[edit] External links

The CAS registry number for this enzyme class is 68652-57-3.

• IUBMB entry for 4.4.1.13

• KEGG entry for 4.4.1.13

• BRENDA entry for 4.4.1.13

• NiceZyme view of 4.4.1.13

• EC2PDB: PDB structures for 4.4.1.13

• PRIAM entry for 4.4.1.13

• PUMA2 entry for 4.4.1.13

• IntEnz: Integrated Enzyme entry for 4.4.1.13

• MetaCyc entry for 4.4.1.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047804: cysteine-S-conjugate beta-lyase

• AMIGO entry for GO code 0047804: cysteine-S-conjugate beta-lyase