Cysteamine dioxygenase

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In enzymology, a cysteamine dioxygenase (EC 1.13.11.19) is an enzyme that catalyzes the chemical reaction

2-aminoethanethiol + O₂ $\rightleftharpoons$ hypotaurine

Thus, the two substrates of this enzyme are 2-aminoethanethiol and O₂, whereas its product is hypotaurine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 2-aminoethanethiol:oxygen oxidoreductase. Other names in common use include persulfurase, cysteamine oxygenase, and cysteamine:oxygen oxidoreductase. This enzyme participates in taurine and hypotaurine metabolism. It employs one cofactor, iron.

[edit] References

IUBMB entry for 1.13.11.19
BRENDA references for 1.13.11.19 (Recommended.)
PubMed references for 1.13.11.19
PubMed Central references for 1.13.11.19
Google Scholar references for 1.13.11.19
Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT (1966). "The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme". J. Biol. Chem. 241: 3189–96. PMID 5912113.
Wood JL, Cavallini D (1967). "Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor". Arch. Biochem. Biophys. 119: 368–72. doi:10.1016/0003-9861(67)90467-5. PMID 6052430.
Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A (1975). "The specificity of cysteamine oxygenase". FEBS. Lett. 56: 348–51. doi:10.1016/0014-5793(75)81124-0. PMID 1157952.
Richerson RB, Ziegler DM (1987). "Cysteamine dioxygenase". Methods. Enzymol. 143: 410–5. PMID 3657558.