Cystatin A

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Cystatin A (stefin A)

PDB rendering based on 1cyu.

Available structures: 1cyu, 1cyv, 1dvc, 1dvd, 1gd3, 1gd4, 1n9j, 1nb3, 1nb5

Identifiers

Symbol(s)

CSTA; STF1; STFA

External IDs

OMIM: 184600 MGI: 3524930 HomoloGene: 3819

Gene ontology
Molecular Function:	• cysteine protease inhibitor activity • structural molecule activity • protein binding, bridging
Cellular Component:	• cornified envelope • intracellular
Biological Process:	• peptide cross-linking • keratinocyte differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005213 (mRNA)
NP_005204 (protein)

NM_001033239 (mRNA)
NP_001028411 (protein)

Location

Chr 3: 123.53 - 123.54 Mb

Chr 16: 36.04 - 36.05 Mb

Pubmed search

[1]

[2]

Cystatin A (stefin A), also known as CSTA, is a human gene.^[1]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.^[1]

[edit] References

^ ^a ^b Entrez Gene: CSTA cystatin A (stefin A).

[edit] Further reading

Järvinen M, Rinne A, Hopsu-Havu VK (1988). "Human cystatins in normal and diseased tissues--a review.". Acta Histochem. 82 (1): 5–18. PMID 3122506.
Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution.". Protein Sci. 6 (1): 5–12. PMID 9007972.
Kos J, Lah TT (1998). "Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review).". Oncol. Rep. 5 (6): 1349–61. PMID 9769367.
Rinne A, Järvinen M, Räsänen O (1979). "A protein reminiscent of the epidermal SH-protease inhibitor occurs in squamous epithelia of man and rat.". Acta Histochem. 63 (2): 183–92. PMID 107702.
Räsänen O, Järvinen M, Rinne A (1979). "Localization of the human SH-protease inhibitor in the epidermis. Immunofluorescent studies.". Acta Histochem. 63 (2): 193–6. PMID 107703.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. PMID 1286667.
Hsieh WT, Barrick JL, Berrettini WH, et al. (1991). "A PstI DNA polymorphism in the human stefin A gene (STF 1).". Nucleic Acids Res. 19 (7): 1722. PMID 1674139.
Madsen P, Rasmussen HH, Leffers H, et al. (1991). "Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin.". J. Invest. Dermatol. 97 (4): 701–12. PMID 1940442.
Hsieh WT, Fong D, Sloane BF, et al. (1991). "Mapping of the gene for human cysteine proteinase inhibitor stefin A, STF1, to chromosome 3cen-q21.". Genomics 9 (1): 207–9. PMID 2004763.
Rinne A, Järvinen M, Dorn A, et al. (1986). "[Low-molecular cysteine protease inhibitors in the human palatal tonsil]". Anatomischer Anzeiger 161 (3): 215–30. PMID 2424340.
Kartasova T, Cornelissen BJ, Belt P, van de Putte P (1987). "Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes.". Nucleic Acids Res. 15 (15): 5945–62. PMID 2442723.
Takeda A, Kaji H, Nakaya K, et al. (1989). "Comparative studies on the primary structure of human cystatin as from epidermis, liver, spleen, and leukocytes.". J. Biochem. 105 (6): 986–91. PMID 2768224.
Strauss M, Stollwerk J, Lenarcic B, et al. (1989). "Chemical synthesis of a gene for human stefin A and its expression in E. coli.". Biol. Chem. Hoppe-Seyler 369 (9): 1019–30. PMID 3067731.
Davies ME, Barrett AJ (1984). "Immunolocalization of human cystatins in neutrophils and lymphocytes.". Histochemistry 80 (4): 373–7. PMID 6429090.
Machleidt W, Borchart U, Fritz H, et al. (1984). "Protein inhibitors of cysteine proteinases. II. Primary structure of stefin, a cytosolic protein inhibitor of cysteine proteinases from human polymorphonuclear granulocytes.". Hoppe-Seyler's Z. Physiol. Chem. 364 (11): 1481–6. PMID 6689312.
Söderström KO, Laato M, Wu P, et al. (1995). "Expression of acid cysteine proteinase inhibitor (ACPI) in the normal human prostate, benign prostatic hyperplasia and adenocarcinoma.". Int. J. Cancer 62 (1): 1–4. PMID 7541394.
Tate S, Ushioda T, Utsunomiya-Tate N, et al. (1995). "Solution structure of a human cystatin A variant, cystatin A2-98 M65L, by NMR spectroscopy. A possible role of the interactions between the N- and C-termini to maintain the inhibitory active form of cystatin A.". Biochemistry 34 (45): 14637–48. PMID 7578072.
Martin JR, Craven CJ, Jerala R, et al. (1995). "The three-dimensional solution structure of human stefin A.". J. Mol. Biol. 246 (2): 331–43. PMID 7869384.
Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.". J. Biol. Chem. 272 (3): 2021–30. PMID 8999895.