Cys-loop receptors

From Wikipedia, the free encyclopedia

The Cys-loop ligand-gated ion channel superfamily is comprised of nicotinic acetylcholine, GABA_A, GABA_C, glycine and 5-HT₃ receptors that are composed of five protein subunits and possess a characteristic loop formed by a disulfide bond between two cysteine residues.

[edit] References

• Sine S, Engel A (2006). "Recent advances in Cys-loop receptor structure and function.". Nature 440 (7083): 448–55. doi:10.1038/nature04708. PMID 16554804. 

[edit] External links

• Overview at gwumc.edu

v • d • e Ion channel, receptor: ligand-gated ion channels Cys-loop receptors 5-HT/serotonin: 5-HT3 (A) GABA: GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ2, γ3, δ, ε, π), GABA C (ρ1, ρ2) Glycine: α1, α2, β Nicotinic acetylcholine: α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, combinations ((α4)2(β2)3, (α7)5, Ganglion type, Muscle type) Ionotropic glutamates AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D) ATP-gated channels Purinergic receptors: P2X (1, 2, 3, 4, 5, 6, 7)