CYR61

From Wikipedia, the free encyclopedia


Cysteine-rich, angiogenic inducer, 61
Identifiers
Symbol(s) CYR61; CCN1; GIG1; IGFBP10
External IDs OMIM: 602369 MGI: 88613 HomoloGene: 1194
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3491 16007
Ensembl ENSG00000142871 ENSMUSG00000028195
Uniprot O00622 Q3TX21
Refseq NM_001554 (mRNA)
NP_001545 (protein)		 NM_010516 (mRNA)
NP_034646 (protein)
Location Chr 1: 85.82 - 85.82 Mb Chr 3: 145.58 - 145.59 Mb
Pubmed search [1] [2]

Cysteine-rich, angiogenic inducer, 61, also known as CYR61, is a human gene.

CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.[supplied by OMIM][1]

[edit] References

  1. ^ Entrez Gene: CYR61 cysteine-rich, angiogenic inducer, 61.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Genini M, Schwalbe P, Scholl FA, Schäfer BW (1996). "Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma.". Int. J. Cancer 66 (4): 571–7. doi:10.1002/(SICI)1097-0215(19960516)66:4<571::AID-IJC24>3.0.CO;2-9. PMID 8635876. 
  • Jay P, Bergé-Lefranc JL, Marsollier C, et al. (1997). "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.". Oncogene 14 (14): 1753–7. doi:10.1038/sj.onc.1200986. PMID 9135077. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Kireeva ML, Lam SC, Lau LF (1998). "Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.". J. Biol. Chem. 273 (5): 3090–6. PMID 9446626. 
  • Kolesnikova TV, Lau LF (1998). "Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells.". Oncogene 16 (6): 747–54. doi:10.1038/sj.onc.1201572. PMID 9488038. 
  • Schütze N, Lechner A, Groll C, et al. (1998). "The human analog of murine cystein rich protein 61 [correction of 16] is a 1alpha,25-dihydroxyvitamin D3 responsive immediate early gene in human fetal osteoblasts: regulation by cytokines, growth factors, and serum.". Endocrinology 139 (4): 1761–70. PMID 9528960. 
  • Martinerie C, Viegas-Pequignot E, Nguyen VC, Perbal B (1998). "Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.". MP, Mol. Pathol. 50 (6): 310–6. PMID 9536281. 
  • Babic AM, Kireeva ML, Kolesnikova TV, Lau LF (1998). "CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6355–60. PMID 9600969. 
  • Jedsadayanmata A, Chen CC, Kireeva ML, et al. (1999). "Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).". J. Biol. Chem. 274 (34): 24321–7. PMID 10446209. 
  • Chen N, Chen CC, Lau LF (2000). "Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.". J. Biol. Chem. 275 (32): 24953–61. doi:10.1074/jbc.M003040200. PMID 10821835. 
  • Albrecht C, von Der Kammer H, Mayhaus M, et al. (2000). "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61.". J. Biol. Chem. 275 (37): 28929–36. doi:10.1074/jbc.M003053200. PMID 10852911. 
  • Chen CC, Chen N, Lau LF (2001). "The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts.". J. Biol. Chem. 276 (13): 10443–52. doi:10.1074/jbc.M008087200. PMID 11120741. 
  • Grzeszkiewicz TM, Kirschling DJ, Chen N, Lau LF (2001). "CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.". J. Biol. Chem. 276 (24): 21943–50. doi:10.1074/jbc.M100978200. PMID 11287419. 
  • Chen CC, Mo FE, Lau LF (2002). "The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.". J. Biol. Chem. 276 (50): 47329–37. doi:10.1074/jbc.M107666200. PMID 11584015. 
  • Tamura I, Rosenbloom J, Macarak E, Chaqour B (2001). "Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.". Am. J. Physiol., Cell Physiol. 281 (5): C1524–32. PMID 11600415. 
  • Xie D, Nakachi K, Wang H, et al. (2002). "Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.". Cancer Res. 61 (24): 8917–23. PMID 11751417. 
  • Leng E, Malcolm T, Tai G, et al. (2002). "Organization and expression of the Cyr61 gene in normal human fibroblasts.". J. Biomed. Sci. 9 (1): 59–67. PMID 11810026. 
  • Tsai MS, Bogart DF, Li P, et al. (2002). "Expression and regulation of Cyr61 in human breast cancer cell lines.". Oncogene 21 (6): 964–73. doi:10.1038/sj.onc.1205131. PMID 11840342. 
  • Schober JM, Chen N, Grzeszkiewicz TM, et al. (2002). "Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions.". Blood 99 (12): 4457–65. PMID 12036876. 
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