Cyproheptadine
From Wikipedia, the free encyclopedia
 |
|
|
Cyproheptadine
|
|
| Systematic (IUPAC) name | |
| 4-(5 H-dibenzo [a,d]cyclohepten-5-ylidene)- 1 -methylpiperidine hydrochloride | |
| Identifiers | |
| CAS number | |
| ATC code | R06 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C21H21N |
| Mol. mass | 287.398 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 96 to 99% |
| Metabolism | Hepatic and renal |
| Half life | 1 to 4 hours |
| Excretion | Fecal and renal |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status |
P(UK) |
| Routes | Oral only |
Cyproheptadine (usually as cyproheptadine hydrochloride, trade name Periactin) is an antihistaminic and antiserotonergic agent. It acts as a 5-HT2 receptor antagonist and also blocks calcium channels.
[edit] Uses
Cyproheptadine is used in the treatment of allergies (specifically hay fever) and is also used to stimulate appetite in underweight people (e.g. anorexia nervosa).
Cyproheptadine is used in serotonin syndrome, a complex of symptoms associated with selective serotonin reuptake inhibitors, especially when taken in excess dose, meperidine and in the disease carcinoid in which serotonin is overproduced by tumor cells.
Cyproheptadine is a useful alternative to benzodiazepine hypnotics in the treatment of insomnia. Cyproheptadine may be superior to benzodiazepines in the treatment of insomnia because cyproheptadine enhances sleep quality and quantity whereas benzodiazepines tend to decrease sleep quality.[1]
Recently, Cyproheptadine has also been prescribed to children and adolescents with frequent migranes.
[edit] Side effects
While not specifically used as a sedative, cyproheptadine causes sedation, likely due to its anti-histamine effects.[citation needed]
Digestive system: epigastric distress (dysphagia), loss of appetite, nausea, vomiting, (it is noted that these side effects are much more common in people with neuromuscular disorders)[citation needed]
Cyproheptadine can also cause Over Sleeping(10 Hours)in Children and Adolescents.
[edit] References
 |
This article needs additional citations for verification. Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (December 2007) |
- ^ Tokunaga S; Takeda Y, Shinomiya K, Hirase M, Kamei C. (Feb 2007). "Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats." (pdf). J Pharmacol Sci. 103 (2): 201–6. doi:. PMID 17287588.
|
|||||||||||||||||||||||||||||
