CYP7B1

From Wikipedia, the free encyclopedia

Cytochrome P450, family 7, subfamily B, polypeptide 1

Identifiers

External IDs

OMIM: 603711 MGI: 104978 HomoloGene: 3544

Gene ontology
Molecular Function:	• monooxygenase activity • iron ion binding • oxysterol 7-alpha-hydroxylase activity • heme binding • metal ion binding
Cellular Component:	• endoplasmic reticulum • microsome • membrane
Biological Process:	• electron transport • lipid metabolic process • bile acid biosynthetic process • steroid metabolic process • cholesterol metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004820 (mRNA)
NP_004811 (protein)

NM_007825 (mRNA)
NP_031851 (protein)

Location

Chr 8: 65.67 - 65.87 Mb

Chr 3: 18.26 - 18.44 Mb

Pubmed search

[1]

[2]

Cytochrome P450, family 7, subfamily B, polypeptide 1, also known as CYP7B1, is a human gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1.

[edit] Further reading

Schwarz M, Lund EG, Russell DW (1998). "Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis.". Curr. Opin. Lipidol. 9 (2): 113–8. PMID 9559267.
Hennebert O, Chalbot S, Alran S, Morfin R (2007). "Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes.". J. Steroid Biochem. Mol. Biol. 104 (3-5): 326–33. doi:10.1016/j.jsbmb.2007.03.026. PMID 17467270.
Tang W, Norlin M (2006). "Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells.". Biochem. Biophys. Res. Commun. 344 (2): 540–6. doi:10.1016/j.bbrc.2006.03.175. PMID 16630558.
Dulos J, van der Vleuten MA, Kavelaars A, et al. (2005). "CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.". Arthritis Rheum. 52 (3): 770–8. doi:10.1002/art.20950. PMID 15751070.
Kim SB, Chalbot S, Pompon D, et al. (2005). "The human cytochrome P4507B1: catalytic activity studies.". J. Steroid Biochem. Mol. Biol. 92 (5): 383–9. doi:10.1016/j.jsbmb.2004.09.005. PMID 15698543.
Martin C, Ross M, Chapman KE, et al. (2004). "CYP7B generates a selective estrogen receptor beta agonist in human prostate.". J. Clin. Endocrinol. Metab. 89 (6): 2928–35. doi:10.1210/jc.2003-031847. PMID 15181079.
Jakobsson J, Karypidis H, Johansson JE, et al. (2005). "A functional C-G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians.". Pharmacogenomics J. 4 (4): 245–50. doi:10.1038/sj.tpj.6500236. PMID 15007371.
Norlin M, Chiang JY (2004). "Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein.". Biochem. Biophys. Res. Commun. 316 (1): 158–64. doi:10.1016/j.bbrc.2004.02.029. PMID 15003524.
Yau JL, Rasmuson S, Andrew R, et al. (2003). "Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease.". Neuroscience 121 (2): 307–14. PMID 14521990.
Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.". J. Hum. Genet. 48 (5): 249–70. doi:10.1007/s10038-003-0021-7. PMID 12721789.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wu Z, Martin KO, Javitt NB, Chiang JY (2000). "Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.". J. Lipid Res. 40 (12): 2195–203. PMID 10588945.
Setchell KD, Schwarz M, O'Connell NC, et al. (1998). "Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease.". J. Clin. Invest. 102 (9): 1690–703. PMID 9802883.