CYP3A5

From Wikipedia, the free encyclopedia

Cytochrome P450, family 3, subfamily A, polypeptide 5

Identifiers

CYP3A5; CP35; P450PCN3; PCN3

External IDs

OMIM: 605325 MGI: 88609 HomoloGene: 88340

Gene ontology
Molecular Function:	• monooxygenase activity • iron ion binding • oxygen binding • heme binding • metal ion binding • unspecific monooxygenase activity
Cellular Component:	• membrane fraction • endoplasmic reticulum • microsome • membrane
Biological Process:	• electron transport • xenobiotic metabolic process • steroid metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_000777 (mRNA)
NP_000768 (protein)

XM_984479 (mRNA)
XP_989573 (protein)

Location

Chr 7: 99.08 - 99.12 Mb

n/a

Pubmed search

[1]

[2]

Cytochrome P450, family 3, subfamily A, polypeptide 5, also known as CYP3A5, is a human gene.

This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene.^[1]

[edit] See also

Cytochrome P450

[edit] References

^ Entrez Gene: CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5.

[edit] Further reading

Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129–65. PMID 9890157.
Lee SJ, Goldstein JA (2006). "Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests.". Pharmacogenomics 6 (4): 357–71. doi:10.1517/14622416.6.4.357. PMID 16004554.
Aoyama T, Yamano S, Waxman DJ, et al. (1989). "Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.". J. Biol. Chem. 264 (18): 10388–95. PMID 2732228.
Schuetz JD, Molowa DT, Guzelian PS (1989). "Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver.". Arch. Biochem. Biophys. 274 (2): 355–65. PMID 2802615.
Murray GI, Pritchard S, Melvin WT, Burke MD (1995). "Cytochrome P450 CYP3A5 in the human anterior pituitary gland.". FEBS Lett. 364 (1): 79–82. PMID 7750548.
Jounaïdi Y, Guzelian PS, Maurel P, Vilarem MJ (1995). "Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.". Biochem. Biophys. Res. Commun. 205 (3): 1741–7. doi:10.1006/bbrc.1994.2870. PMID 7811260.
McKinnon RA, Burgess WM, Hall PM, et al. (1995). "Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues.". Gut 36 (2): 259–67. PMID 7883227.
Kolars JC, Lown KS, Schmiedlin-Ren P, et al. (1995). "CYP3A gene expression in human gut epithelium.". Pharmacogenetics 4 (5): 247–59. PMID 7894497.
Lown KS, Kolars JC, Thummel KE, et al. (1995). "Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test.". Drug Metab. Dispos. 22 (6): 947–55. PMID 7895614.
Schuetz JD, Beach DL, Guzelian PS (1994). "Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver.". Pharmacogenetics 4 (1): 11–20. PMID 8004129.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Schuetz JD, Schuetz EG, Thottassery JV, et al. (1996). "Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.". Mol. Pharmacol. 49 (1): 63–72. PMID 8569713.
Jounaïdi Y, Hyrailles V, Gervot L, Maurel P (1996). "Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?". Biochem. Biophys. Res. Commun. 221 (2): 466–70. PMID 8619878.
Hakkola J, Pasanen M, Hukkanen J, et al. (1996). "Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta.". Biochem. Pharmacol. 51 (4): 403–11. PMID 8619884.
Hakkola J, Raunio H, Purkunen R, et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.". Biochem. Pharmacol. 52 (2): 379–83. PMID 8694864.
Huang Z, Fasco MJ, Figge HL, et al. (1997). "Expression of cytochromes P450 in human breast tissue and tumors.". Drug Metab. Dispos. 24 (8): 899–905. PMID 8869826.
Kivistö KT, Bookjans G, Fromm MF, et al. (1997). "Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue.". British journal of clinical pharmacology 42 (3): 387–9. PMID 8877031.
Janardan SK, Lown KS, Schmiedlin-Ren P, et al. (1997). "Selective expression of CYP3A5 and not CYP3A4 in human blood.". Pharmacogenetics 6 (5): 379–85. PMID 8946469.
Anttila S, Hukkanen J, Hakkola J, et al. (1997). "Expression and localization of CYP3A4 and CYP3A5 in human lung.". Am. J. Respir. Cell Mol. Biol. 16 (3): 242–9. PMID 9070608.
Hukkanen J, Hakkola J, Anttila S, et al. (1997). "Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.". Mol. Carcinog. 20 (2): 224–30. PMID 9364212.