CYP2B6

From Wikipedia, the free encyclopedia

cytochrome P450, family 2, subfamily B, polypeptide 6
Identifiers
Symbol CYP2B6
Entrez 1555
HUGO 2615
OMIM 123930
RefSeq NM_000767
UniProt P20813
Other data
Locus Chr. 19 q13.2

CYP2B6 is a member of the Cytochrome P450 group of enzymes. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances.






[edit] CYP2B6 Ligands

Substrates Inhibitors Inducers
Often mentioned [1]:
Bupropion (antidepressant)
Cyclophosphamide (Alkylating antineoplastic agent)
Efavirenz (NNRTI)
Ifosfamide (Alkylating antineoplastic agent)

Other:
Alfentanil (opioid analgesic)
Nevirapine (NNRTI)
Propofol (anesthetic)
tamoxifen (SERM)
Valproic acid (anticonvulsant , mood-stabilizing)
Artemisinin (against malaria)
Pethidine (analgesic)
Nicotine (stimulant)
Sertraline (SSRI)
thiotepa (Alkylating antineoplastic agent)

Strong [2]:
Orphenadrine (analgesic)


unspecified:
Paroxetine (SSRI)
fluoxetine (SSRI)
Estradiol (sex hormone)
Phencyclidine (dissociative)
ritonavir (antiretroviral)
sertraline (SSRI)
thiotepa (Alkylating antineoplastic agent)
ticlopidine (antiplatelet)

Often mentioned [1]:
carbamazepine (anticonvulsant, mood stabilizer)
rifampicin (bactericidal)

Other:
artemisinin (against malaria)
clotrimazole (antifungal)
ifosfamide (Alkylating antineoplastic agent)
glucocorticoids (antiinflammatory)
phenobarbital (anticonvulsant )
phenytoin (antiepileptic)
ritonavir (antiretroviral)

[edit] References

  1. ^ a b Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
  2. ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)

[edit] External links