CYP2A

From Wikipedia, the free encyclopedia

Cytochrome P450, family 2, subfamily A

Identifiers

CYP2A; CYP1; CYP2; P450C2; P450C2A; P450PB

Gene ontology

Orthologs

Human

Mouse

Entrez

1546

n/a

Pubmed search

[1]

n/a

Cytochrome P450, family 2, subfamily A, also known as CYP2A, is a human gene.^[1]

The cytochrome P450 superfamily of enzymes are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP2 gene cluster on chromosome 19q13.2 includes several genes and pseudogenes from the CYP2A, CYP2B, and CYP2F subfamilies.^[1]

[edit] References

^ ^a ^b Entrez Gene: CYP2A cytochrome P450, family 2, subfamily A.

[edit] Further reading

Fernandez-Salguero P, Gonzalez FJ (1995). "The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.". Pharmacogenetics 5 Spec No: S123-8. PMID 7581481.
Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129-65. PMID 9890157.
Raunio H, Rautio A, Pelkonen O (1999). "The CYP2A subfamily: function, expression and genetic polymorphism.". IARC Sci. Publ. (148): 197-207. PMID 10493259.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1-18. PMID 15128046.
Nhamburo PT, Kimura S, McBride OW, et al. (1990). "The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping.". Biochemistry 29 (23): 5491-9. PMID 1974816.
Miles JS, McLaren AW, Gonzalez FJ, Wolf CR (1990). "Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4.". Nucleic Acids Res. 18 (1): 189. PMID 2308828.
Yamano S, Nhamburo PT, Aoyama T, et al. (1990). "cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.". Biochemistry 28 (18): 7340-8. PMID 2573390.
Miles JS, Bickmore W, Brook JD, et al. (1989). "Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.". Nucleic Acids Res. 17 (8): 2907-17. PMID 2726448.
Miles JS, McLaren AW, Wolf CR (1989). "Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.". Nucleic Acids Res. 17 (20): 8241-55. PMID 2813061.
Fernandez-Salguero P, Hoffman SM, Cholerton S, et al. (1995). "A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.". Am. J. Hum. Genet. 57 (3): 651-60. PMID 7668294.
Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133-45. PMID 8432525.
Hoffman SM, Fernandez-Salguero P, Gonzalez FJ, Mohrenweiser HW (1996). "Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.". J. Mol. Evol. 41 (6): 894-900. PMID 8587134.
Rylander T, Neve EP, Ingelman-Sundberg M, Oscarson M (2001). "Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1).". Biochem. Biophys. Res. Commun. 281 (2): 529-35. doi:10.1006/bbrc.2001.4390. PMID 11181079.