CYP24A1

From Wikipedia, the free encyclopedia

Cytochrome P450, family 24, subfamily A, polypeptide 1

Identifiers

CYP24A1; CP24; CYP24; MGC126273; MGC126274; P450-CC24

External IDs

OMIM: 126065 MGI: 88593 HomoloGene: 68094

Gene ontology
Molecular Function:	• monooxygenase activity • iron ion binding • 25-hydroxycholecalciferol-24-hydroxylase activity • heme binding • 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity • metal ion binding
Cellular Component:	• cellular_component • mitochondrion
Biological Process:	• electron transport • vitamin D metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000782 (mRNA)
NP_000773 (protein)

NM_009996 (mRNA)
NP_034126 (protein)

Location

Chr 20: 52.2 - 52.22 Mb

Chr 2: 170.17 - 170.19 Mb

Pubmed search

[1]

[2]

Cytochrome P450, family 24, subfamily A, polypeptide 1, also known as CYP24A1, is a human gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system.^[1]

[edit] References

^ ^a ^b Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1.

[edit] Further reading

Okuda K, Usui E, Ohyama Y (1995). "Recent progress in enzymology and molecular biology of enzymes involved in vitamin D metabolism.". J. Lipid Res. 36 (8): 1641–52. PMID 7595086.
Chen KS, DeLuca HF (1995). "Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements.". Biochim. Biophys. Acta 1263 (1): 1–9. PMID 7632726.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Chen ML, Heinrich G, Ohyama YI, et al. (1994). "Expression of 25-hydroxyvitamin D3-24-hydroxylase mRNA in cultured human keratinocytes.". Proc. Soc. Exp. Biol. Med. 207 (1): 57–61. PMID 7938037.
Labuda M, Lemieux N, Tihy F, et al. (1994). "Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets.". J. Bone Miner. Res. 8 (11): 1397–406. PMID 8266831.
Hahn CN, Baker E, Laslo P, et al. (1993). "Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20q13.2-->q13.3.". Cytogenet. Cell Genet. 62 (4): 192–3. PMID 8440135.
Chen KS, Prahl JM, DeLuca HF (1993). "Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA.". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4543–7. PMID 8506296.
Bland R, Walker EA, Hughes SV, et al. (1999). "Constitutive expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium.". Endocrinology 140 (5): 2027–34. PMID 10218951.
Taniguchi T, Eto TA, Shiotsuki H, et al. (2001). "Newly established assay method for 25-hydroxyvitamin D3 24-hydroxylase revealed much lower Km for 25-hydroxyvitamin D3 than for 1alpha,25-dihydroxyvitamin D3.". J. Bone Miner. Res. 16 (1): 57–62. PMID 11149490.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Farhan H, Cross HS (2003). "Transcriptional inhibition of CYP24 by genistein.". Ann. N. Y. Acad. Sci. 973: 459–62. PMID 12485911.
Theodoropoulos C, Demers C, Delvin E, et al. (2003). "Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine.". Clin. Endocrinol. (Oxf) 58 (4): 489–99. PMID 12641633.
Fritsche J, Mondal K, Ehrnsperger A, et al. (2004). "Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells.". Blood 102 (9): 3314–6. doi:10.1182/blood-2002-11-3521. PMID 12855575.
Nguyen TM, Lieberherr M, Fritsch J, et al. (2004). "The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations.". J. Biol. Chem. 279 (9): 7591–7. doi:10.1074/jbc.M309517200. PMID 14665637.
Mimori K, Tanaka Y, Yoshinaga K, et al. (2004). "Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer.". Ann. Oncol. 15 (2): 236–41. PMID 14760115.
Sawada N, Kusudo T, Sakaki T, et al. (2004). "Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1.". Biochemistry 43 (15): 4530–7. doi:10.1021/bi030207f. PMID 15078099.
Kusudo T, Sakaki T, Abe D, et al. (2004). "Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1.". Biochem. Biophys. Res. Commun. 321 (4): 774–82. doi:10.1016/j.bbrc.2004.07.040. PMID 15358094.
Pascussi JM, Robert A, Nguyen M, et al. (2005). "Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.". J. Clin. Invest. 115 (1): 177–86. doi:10.1172/JCI200521867. PMID 15630458.