Cyclohexa-1,5-dienecarbonyl-CoA hydratase

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In enzymology, a cyclohexa-1,5-dienecarbonyl-CoA hydratase (EC 4.2.1.100) is an enzyme that catalyzes the chemical reaction

6-hydroxycyclohex-1-enecarbonyl-CoA $\rightleftharpoons$ cyclohexa-1,5-dienecarbonyl-CoA + H₂O

Hence, this enzyme has one substrate, 6-hydroxycyclohex-1-enecarbonyl-CoA, and two products, cyclohexa-1,5-dienecarbonyl-CoA and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming). Other names in common use include cyclohexa-1,5-diene-1-carbonyl-CoA hydratase, dienoyl-CoA hydratase, and cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect). This enzyme participates in benzoate degradation via coa ligation.

[edit] References

IUBMB entry for 4.2.1.100
BRENDA references for 4.2.1.100 (Recommended.)
PubMed references for 4.2.1.100
PubMed Central references for 4.2.1.100
Google Scholar references for 4.2.1.100
Laempe D, Eisenreich W, Bacher A, Fuchs G (1998). "Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica". Eur. J. Biochem. 255: 618–27. doi:10.1046/j.1432-1327.1998.2550618.x. PMID 9738901.
Harwood CS, Gibson J (1997). "Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?". J. Bacteriol. 179: 301–9. PMID 8990279.
Koch J, Eisenreich W, Bacher A, Fuchs G (1993). "Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism". Eur. J. Biochem. 211: 649–61. doi:10.1111/j.1432-1033.1993.tb17593.x. PMID 8436125.