Cyclic neutropenia

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Cyclic neutropenia
Classification and external resources
OMIM 162800
DiseasesDB 30103

Cyclic neutropenia (or cyclical neutropenia) is a form of neutropenia which tends to occur every three weeks and lasting three to six days at a time due to changing rates of cell production by the bone marrow.

It is often present among several members of the same family.

Cyclic neutropenia is the result of autosomal dominantly inherited mutations in ELA2, the gene encoding neutrophil elastase.[1]

[edit] References

  1. ^ Sera Y, Kawaguchi H, Nakamura K, et al (2005). "A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia". Haematologica 90 (8): 1032–41. PMID 16079102. 
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