Cyanocobalamin reductase (cyanide-eliminating)

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In enzymology, a cyanocobalamin reductase (cyanide-eliminating) (EC 1.16.1.6) is an enzyme that catalyzes the chemical reaction

cob(I)alamin + cyanide + NADP⁺ cyanocob(III)alamin + NADPH + H⁺

The 3 substrates of this enzyme are cob(I)alamin, cyanide, and NADP⁺, whereas its 3 products are cyanocob(III)alamin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cob(I)alamin, cyanide:NADP+ oxidoreductase. Other names in common use include cyanocobalamin reductase, cyanocobalamin reductase (NADPH, cyanide-eliminating), cyanocobalamin reductase (NADPH, CN-eliminating), and NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating). This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, FAD.

[edit] References

• IUBMB entry for 1.16.1.6
• BRENDA references for 1.16.1.6 (Recommended.)
• PubMed references for 1.16.1.6
• PubMed Central references for 1.16.1.6
• Google Scholar references for 1.16.1.6
• Watanabe F, Oki Y, Nakano Y, Kitaoka S (Tokyo). "Occurrence and characterization of cyanocobalamin reductase (NADPH CN-eliminating) involved in decyanation of cyanocobalamin in Euglena gracilis". J. Nutr. Sci. Vitaminol.: 1–10. PMID 3134526. 

[edit] External links

The CAS registry number for this enzyme class is 131145-00-1.

• IUBMB entry for 1.16.1.6

• KEGG entry for 1.16.1.6

• BRENDA entry for 1.16.1.6

• NiceZyme view of 1.16.1.6

• EC2PDB: PDB structures for 1.16.1.6

• PRIAM entry for 1.16.1.6

• PUMA2 entry for 1.16.1.6

• IntEnz: Integrated Enzyme entry for 1.16.1.6

• MetaCyc entry for 1.16.1.6

• Atomic-resolution structures of enzymes belonging to this class