CX3CR1

From Wikipedia, the free encyclopedia


Chemokine (C-X3-C motif) receptor 1
Identifiers
Symbol(s) CX3CR1; CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28
External IDs OMIM: 601470 MGI: 1333815 HomoloGene: 20350
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1524 13051
Ensembl ENSG00000168329 ENSMUSG00000052336
Uniprot P49238 Q543X3
Refseq NM_001337 (mRNA)
NP_001328 (protein)		 XM_983192 (mRNA)
XP_988286 (protein)
Location Chr 3: 39.28 - 39.3 Mb Chr 9: 119.75 - 119.92 Mb
Pubmed search [1] [2]

Only one member belongs to the CX3C sub-family of chemokine receptors - CX3CR1. As the name suggests, this receptor binds the chemokine CX3CL1 (also called neurotactin or fractalkine).

Expression of this receptor appears to be associated with lymphocytes.[1]

[edit] References

  1. ^ Imai et al. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530, 1997.

[edit] Further reading

  • Robertson MJ (2002). "Role of chemokines in the biology of natural killer cells.". J. Leukoc. Biol. 71 (2): 173–83. PMID 11818437. 
  • Raport CJ, Schweickart VL, Eddy RL, et al. (1995). "The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues.". Gene 163 (2): 295–9. PMID 7590284. 
  • Combadiere C, Ahuja SK, Murphy PM (1995). "Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene.". DNA Cell Biol. 14 (8): 673–80. PMID 7646814. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Imai T, Hieshima K, Haskell C, et al. (1997). "Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.". Cell 91 (4): 521–30. PMID 9390561. 
  • Combadiere C, Salzwedel K, Smith ED, et al. (1998). "Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.". J. Biol. Chem. 273 (37): 23799–804. PMID 9726990. 
  • Mizoue LS, Bazan JF, Johnson EC, Handel TM (1999). "Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1.". Biochemistry 38 (5): 1402–14. doi:10.1021/bi9820614. PMID 9931005. 
  • Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.". Cytogenet. Cell Genet. 87 (3-4): 265–8. PMID 10702689. 
  • Faure S, Meyer L, Costagliola D, et al. (2000). "Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.". Science 287 (5461): 2274–7. PMID 10731151. 
  • Yoneda O, Imai T, Goda S, et al. (2000). "Fractalkine-mediated endothelial cell injury by NK cells.". J. Immunol. 164 (8): 4055–62. PMID 10754298. 
  • Meucci O, Fatatis A, Simen AA, Miller RJ (2000). "Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 8075–80. doi:10.1073/pnas.090017497. PMID 10869418. 
  • Papadopoulos EJ, Fitzhugh DJ, Tkaczyk C, et al. (2000). "Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin.". Eur. J. Immunol. 30 (8): 2355–61. PMID 10940926. 
  • Moatti D, Faure S, Fumeron F, et al. (2001). "Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease.". Blood 97 (7): 1925–8. PMID 11264153. 
  • Foussat A, Bouchet-Delbos L, Berrebi D, et al. (2001). "Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients.". Blood 98 (6): 1678–86. PMID 11535497. 
  • Dichmann S, Herouy Y, Purlis D, et al. (2002). "Fractalkine induces chemotaxis and actin polymerization in human dendritic cells.". Inflamm. Res. 50 (11): 529–33. PMID 11766992. 
  • Brand S, Sakaguchi T, Gu X, et al. (2002). "Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells.". Gastroenterology 122 (1): 166–77. PMID 11781291. 
  • Utaipat U, Duerr A, Rudolph DL, et al. (2002). "Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives.". AIDS Res. Hum. Retroviruses 18 (1): 1–11. doi:10.1089/088922202753394664. PMID 11804551. 
  • Fong AM, Alam SM, Imai T, et al. (2002). "CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion.". J. Biol. Chem. 277 (22): 19418–23. doi:10.1074/jbc.M201396200. PMID 11909868. 

[edit] External links

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G protein-coupled receptors, cytokine receptors: chemokine receptors
CC chemokine receptors
CXC chemokine receptors
Other
CCBP2 - CMKLR1 - CX3CR1 - XCR1