CUL7

From Wikipedia, the free encyclopedia

Cullin 7

PDB rendering based on 2jng.

Available structures: 2jng

Identifiers

Symbol(s)

CUL7; KIAA0076; dJ20C7.5

External IDs

OMIM: 609577 MGI: 1913765 HomoloGene: 56683

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• anaphase-promoting complex
Biological Process:	• vasculogenesis • proteolysis • ubiquitin cycle • cell cycle • regulation of mitotic metaphase/anaphase transition • regulation of endothelial cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014780 (mRNA)
NP_055595 (protein)

NM_025611 (mRNA)
NP_079887 (protein)

Location

Chr 6: 43.11 - 43.13 Mb

Chr 17: 46.11 - 46.13 Mb

Pubmed search

[1]

[2]

Cullin 7, also known as CUL7, is a human gene.^[1]

[edit] References

^ Entrez Gene: CUL7 cullin 7.

[edit] Further reading

Kim SS, Shago M, Kaustov L, et al. (2007). "CUL7 is a novel antiapoptotic oncogene.". Cancer Res. 67 (20): 9616–22. doi:10.1158/0008-5472.CAN-07-0644. PMID 17942889.
Jung P, Verdoodt B, Bailey A, et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function.". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. doi:10.1073/pnas.0609467104. PMID 17586686.
Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes.". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.
Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7.". Biochem. Biophys. Res. Commun. 348 (1): 132–8. doi:10.1016/j.bbrc.2006.07.013. PMID 16875676.
Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.". Oncogene 25 (33): 4534–48. doi:10.1038/sj.onc.1209490. PMID 16547496.
Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome.". Nat. Genet. 37 (10): 1119–24. doi:10.1038/ng1628. PMID 16142236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Arai T, Kasper JS, Skaar JR, et al. (2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis.". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9855–60. doi:10.1073/pnas.1733908100. PMID 12904573.
Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMID 12481031.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. PMID 7584044.