CUL4B

From Wikipedia, the free encyclopedia

Cullin 4B

PDB rendering based on 2do7.

Available structures: 2do7

Identifiers

Symbol(s)

CUL4B; DKFZp686F1470; KIAA0695

External IDs

OMIM: 300304 MGI: 1919834 HomoloGene: 2660

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• cellular_component
Biological Process:	• DNA repair • ubiquitin cycle • cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001079872 (mRNA)
NP_001073341 (protein)

NM_028288 (mRNA)
NP_082564 (protein)

Location

Chr X: 119.54 - 119.59 Mb

Chr X: 34.78 - 34.82 Mb

Pubmed search

[1]

[2]

Cullin 4B, also known as CUL4B, is a human gene.^[1]

This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CUL4B cullin 4B.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Kipreos ET, Lander LE, Wing JP, et al. (1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.". Cell 85 (6): 829-39. PMID 8681378.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169-76. PMID 9734811.
Wada H, Yeh ET, Kamitani T (1999). "Identification of NEDD8-conjugation site in human cullin-2.". Biochem. Biophys. Res. Commun. 257 (1): 100-5. doi:10.1006/bbrc.1999.0339. PMID 10092517.
Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.". Mol. Cell 3 (4): 535-41. PMID 10230407.
Hori T, Osaka F, Chiba T, et al. (2000). "Covalent modification of all members of human cullin family proteins by NEDD8.". Oncogene 18 (48): 6829-34. doi:10.1038/sj.onc.1203093. PMID 10597293.
Jones EA, Clement-Jones M, Wilson DI (2000). "JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype.". J. Med. Genet. 37 (9): 658-62. PMID 10978356.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zheng J, Yang X, Harrell JM, et al. (2003). "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.". Mol. Cell 10 (6): 1519-26. PMID 12504026.
Min KW, Hwang JW, Lee JS, et al. (2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity.". J. Biol. Chem. 278 (18): 15905-10. doi:10.1074/jbc.M213070200. PMID 12609982.
Higa LA, Mihaylov IS, Banks DP, et al. (2004). "Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.". Nat. Cell Biol. 5 (11): 1008-15. doi:10.1038/ncb1061. PMID 14578910.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Higa LA, Yang X, Zheng J, et al. (2006). "Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation.". Cell Cycle 5 (1): 71-7. PMID 16322693.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Senga T, Sivaprasad U, Zhu W, et al. (2006). "PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.". J. Biol. Chem. 281 (10): 6246-52. doi:10.1074/jbc.M512705200. PMID 16407252.
Li T, Santockyte R, Shen RF, et al. (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.". Arch. Biochem. Biophys. 453 (1): 70-4. doi:10.1016/j.abb.2006.03.002. PMID 16620772.
Wang H, Zhai L, Xu J, et al. (2006). "Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.". Mol. Cell 22 (3): 383-94. doi:10.1016/j.molcel.2006.03.035. PMID 16678110.