CUL4A

From Wikipedia, the free encyclopedia

Cullin 4A

PDB rendering based on 2do7.

Available structures: 2do7, 2hye

Identifiers

Symbol(s)

CUL4A;

External IDs

OMIM: 603137 MGI: 1914487 HomoloGene: 81724

Gene ontology
Molecular Function:	• protein binding
Biological Process:	• G1/S transition of mitotic cell cycle • DNA repair • ubiquitin cycle • cell cycle • cell cycle arrest • negative regulation of cell proliferation • induction of apoptosis by intracellular signals

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001008895 (mRNA)
NP_001008895 (protein)

NM_146207 (mRNA)
NP_666319 (protein)

Location

Chr 13: 112.91 - 112.97 Mb

Chr 8: 13.11 - 13.15 Mb

Pubmed search

[1]

[2]

Cullin 4A, also known as CUL4A, is a human gene.^[1]

[edit] References

^ Entrez Gene: CUL4A Cullin 4A.

[edit] Further reading

Kipreos ET, Lander LE, Wing JP, et al. (1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.". Cell 85 (6): 829–39. PMID 8681378.
Osaka F, Kawasaki H, Aida N, et al. (1998). "A new NEDD8-ligating system for cullin-4A.". Genes Dev. 12 (15): 2263–8. PMID 9694792.
Chen LC, Manjeshwar S, Lu Y, et al. (1998). "The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers.". Cancer Res. 58 (16): 3677–83. PMID 9721878.
Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.". Mol. Cell 3 (4): 535–41. PMID 10230407.
Hori T, Osaka F, Chiba T, et al. (2000). "Covalent modification of all members of human cullin family proteins by NEDD8.". Oncogene 18 (48): 6829–34. doi:10.1038/sj.onc.1203093. PMID 10597293.
Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.". Science 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
Chen X, Zhang Y, Douglas L, Zhou P (2002). "UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation.". J. Biol. Chem. 276 (51): 48175–82. doi:10.1074/jbc.M106808200. PMID 11673459.
Yasui K, Arii S, Zhao C, et al. (2002). "TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.". Hepatology 35 (6): 1476–84. doi:10.1053/jhep.2002.33683. PMID 12029633.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu J, Furukawa M, Matsumoto T, Xiong Y (2003). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.". Mol. Cell 10 (6): 1511–8. PMID 12504025.
Min KW, Hwang JW, Lee JS, et al. (2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity.". J. Biol. Chem. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.". Cell 113 (3): 357–67. PMID 12732143.
Higa LA, Mihaylov IS, Banks DP, et al. (2004). "Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.". Nat. Cell Biol. 5 (11): 1008–15. doi:10.1038/ncb1061. PMID 14578910.
Wertz IE, O'Rourke KM, Zhang Z, et al. (2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.". Science 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. PMID 15009096.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.
Hu J, McCall CM, Ohta T, Xiong Y (2004). "Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.". Nat. Cell Biol. 6 (10): 1003–9. doi:10.1038/ncb1172. PMID 15448697.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Nag A, Bagchi S, Raychaudhuri P (2005). "Cul4A physically associates with MDM2 and participates in the proteolysis of p53.". Cancer Res. 64 (22): 8152–5. doi:10.1158/0008-5472.CAN-04-2598. PMID 15548678.
Matsuda N, Azuma K, Saijo M, et al. (2005). "DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.". DNA Repair (Amst.) 4 (5): 537–45. doi:10.1016/j.dnarep.2004.12.012. PMID 15811626.