CUL3

From Wikipedia, the free encyclopedia

Cullin 3

PDB rendering based on 1iuy.

Available structures: 1iuy

Identifiers

Symbol(s)

CUL3;

External IDs

OMIM: 603136 MGI: 1347360 HomoloGene: 2661

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus
Biological Process:	• G1/S transition of mitotic cell cycle • ubiquitin cycle • cell cycle • cell cycle arrest • positive regulation of cell proliferation • induction of apoptosis by intracellular signals

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003590 (mRNA)
NP_003581 (protein)

XM_976272 (mRNA)
XP_981366 (protein)

Location

Chr 2: 225.04 - 225.16 Mb

Chr 1: 80.15 - 80.22 Mb

Pubmed search

[1]

[2]

Cullin 3, also known as CUL3, is a human gene.^[1]

[edit] References

^ Entrez Gene: CUL3 cullin 3.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Kipreos ET, Lander LE, Wing JP, et al. (1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.". Cell 85 (6): 829-39. PMID 8681378.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Michel JJ, Xiong Y (1998). "Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.". Cell Growth Differ. 9 (6): 435-49. PMID 9663463.
Du M, Sansores-Garcia L, Zu Z, Wu KK (1998). "Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family.". J. Biol. Chem. 273 (38): 24289-92. PMID 9733711.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169-76. PMID 9734811.
Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.". Mol. Cell 3 (4): 535-41. PMID 10230407.
Singer JD, Gurian-West M, Clurman B, Roberts JM (1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.". Genes Dev. 13 (18): 2375-87. PMID 10500095.
Hori T, Osaka F, Chiba T, et al. (2000). "Covalent modification of all members of human cullin family proteins by NEDD8.". Oncogene 18 (48): 6829-34. doi:10.1038/sj.onc.1203093. PMID 10597293.
Maeda I, Ohta T, Koizumi H, Fukuda M (2001). "In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3.". FEBS Lett. 494 (3): 181-5. PMID 11311237.
Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.". Science 292 (5520): 1382-5. doi:10.1126/science.1059780. PMID 11337588.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Min KW, Hwang JW, Lee JS, et al. (2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity.". J. Biol. Chem. 278 (18): 15905-10. doi:10.1074/jbc.M213070200. PMID 12609982.
Kobayashi A, Kang MI, Okawa H, et al. (2004). "Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.". Mol. Cell. Biol. 24 (16): 7130-9. doi:10.1128/MCB.24.16.7130-7139.2004. PMID 15282312.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Furukawa M, Xiong Y (2005). "BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.". Mol. Cell. Biol. 25 (1): 162-71. doi:10.1128/MCB.25.1.162-171.2005. PMID 15601839.
Hernández-Muñoz I, Lund AH, van der Stoop P, et al. (2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7635-40. doi:10.1073/pnas.0408918102. PMID 15897469.
Lu L, Zhou ZM, Huang XY, et al. (2005). "Identification and characterization of cul-3b, a novel hominine CUL-3 transcript variant.". Asian J. Androl. 7 (2): 205-11. doi:10.1111/j.1745-7262.2005.00024.x. PMID 15897978.