CUGBP2

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CUG triplet repeat, RNA binding protein 2
PDB rendering based on 2cpz.
Available structures: 2cpz
Identifiers
Symbol(s) CUGBP2; BRUNOL3; ETR-3; NAPOR
External IDs OMIM: 602538 MGI: 1338822 HomoloGene: 4783
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10659 14007
Ensembl ENSG00000048740 ENSMUSG00000002107
Refseq NM_001025076 (mRNA)
NP_001020247 (protein)		 NM_183219 (mRNA)
NP_899042 (protein)
Location Chr 10: 11.25 - 11.42 Mb Chr 2: 6.46 - 6.8 Mb
Pubmed search [1] [2]

CUG triplet repeat, RNA binding protein 2, also known as CUGBP2, is a human gene.[1]

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: CUGBP2 CUG triplet repeat, RNA binding protein 2.

[edit] Further reading

  • Hwang DM, Hwang WS, Liew CC (1995). "Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system.". J. Mol. Cell. Cardiol. 26 (10): 1329–33. doi:10.1006/jmcc.1994.1151. PMID 7869393. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Lu X, Timchenko NA, Timchenko LT (1999). "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy.". Hum. Mol. Genet. 8 (1): 53–60. PMID 9887331. 
  • Choi DK, Ito T, Tsukahara F, et al. (1999). "Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein.". Gene 237 (1): 135–42. PMID 10524244. 
  • Good PJ, Chen Q, Warner SJ, Herring DC (2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.". J. Biol. Chem. 275 (37): 28583–92. doi:10.1074/jbc. M003083200. PMID 10893231. 
  • Ladd AN, Charlet N, Cooper TA (2001). "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMID 11158314. 
  • Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia.". Genomics 74 (3): 396–401. doi:10.1006/geno.2001.6558. PMID 11414768. 
  • Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor.". J. Biol. Chem. 276 (50): 47338–51. doi:10.1074/jbc. M104911200. PMID 11577082. 
  • Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p.". J. Mol. Med. 80 (7): 431–42. doi:10.1007/s00109-002-0331-9. PMID 12110949. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mukhopadhyay D, Houchen CW, Kennedy S, et al. (2003). "Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.". Mol. Cell 11 (1): 113–26. PMID 12535526. 
  • Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMID 14973222. 
  • Mukhopadhyay D, Jung J, Murmu N, et al. (2004). "CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury.". Ann. N. Y. Acad. Sci. 1010: 504–9. PMID 15033780. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556. 
  • Murmu N, Jung J, Mukhopadhyay D, et al. (2004). "Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage.". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13873–8. doi:10.1073/pnas.0406066101. PMID 15358864. 
  • Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo.". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMID 15894795. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Chen Z, Eggerman TL, Patterson AP (2007). "ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components.". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G53–65. doi:10.1152/ajpgi.00118.2006. PMID 16920700. 
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