CTDSPL

From Wikipedia, the free encyclopedia

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

PDB rendering based on 2hhl.

Available structures: 2hhl

Identifiers

Symbol(s)

CTDSPL; C3orf8; HYA22; PSR1; SCP3

External IDs

OMIM: 608592 MGI: 1916524 HomoloGene: 48377

Gene ontology
Molecular Function:	• molecular_function • phosphoric monoester hydrolase activity
Cellular Component:	• cellular_component • nucleus
Biological Process:	• biological_process

Orthologs

Human

Mouse

Refseq

NM_001008392 (mRNA)
NP_001008393 (protein)

XM_001001463 (mRNA)
XP_001001463 (protein)

Location

Chr 3: 37.88 - 38 Mb

Chr 9: 118.78 - 118.89 Mb

Pubmed search

[1]

[2]

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like, also known as CTDSPL, is a human gene.^[1]

[edit] References

^ Entrez Gene: CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like.

[edit] Further reading

Ishikawa S, Kai M, Tamari M, et al. (1997). "Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line.". DNA Res. 4 (1): 35–43. PMID 9179494.
O'Keeffe B, Fong Y, Chen D, et al. (2000). "Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription.". J. Biol. Chem. 275 (1): 279–87. PMID 10617616.
Kim JB, Sharp PA (2001). "Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.". J. Biol. Chem. 276 (15): 12317–23. doi:10.1074/jbc.M010908200. PMID 11145967.
Ramanathan Y, Rajpara SM, Reza SM, et al. (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.". J. Biol. Chem. 276 (14): 10913–20. doi:10.1074/jbc.M010975200. PMID 11278802.
Zhou M, Nekhai S, Bharucha DC, et al. (2002). "TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription.". J. Biol. Chem. 276 (48): 44633–40. doi:10.1074/jbc.M107466200. PMID 11572868.
Lin X, Taube R, Fujinaga K, Peterlin BM (2002). "P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.". J. Biol. Chem. 277 (19): 16873–8. doi:10.1074/jbc.M200117200. PMID 11884399.
Kim YK, Bourgeois CF, Isel C, et al. (2002). "Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation.". Mol. Cell. Biol. 22 (13): 4622–37. PMID 12052871.
Protopopov A, Kashuba V, Zabarovska VI, et al. (2003). "An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies.". Cancer Res. 63 (2): 404–12. PMID 12543795.
Yeo M, Lin PS, Dahmus ME, Gill GN (2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.". J. Biol. Chem. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
Pinhero R, Liaw P, Bertens K, Yankulov K (2004). "Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II.". Eur. J. Biochem. 271 (5): 1004–14. PMID 15009212.
Kashuba VI, Li J, Wang F, et al. (2004). "RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies.". Proc. Natl. Acad. Sci. U.S.A. 101 (14): 4906–11. doi:10.1073/pnas.0401238101. PMID 15051889.