CTBP2

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C-terminal binding protein 2
PDB rendering based on 2ome.
Available structures: 2ome
Identifiers
Symbol(s) CTBP2;
External IDs OMIM: 602619 MGI: 1201686 HomoloGene: 75187
Orthologs
Human Mouse
Entrez 1488 13017
Ensembl n/a ENSMUSG00000030970
Uniprot n/a Q3UGL5
Refseq NM_001329 (mRNA)
NP_001320 (protein)		 NM_009980 (mRNA)
NP_034110 (protein)
Location n/a Chr 7: 132.83 - 132.96 Mb
Pubmed search [1] [2]

C-terminal binding protein 2, also known as CTBP2, is a human gene.[1]

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.[1]

[edit] References

  1. ^ a b Entrez Gene: CTBP2 C-terminal binding protein 2.

[edit] Further reading

  • Chinnadurai G (2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis.". Mol. Cell 9 (2): 213–24. PMID 11864595. 
  • Schaeper U, Boyd JM, Verma S, et al. (1995). "Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.". Proc. Natl. Acad. Sci. U.S.A. 92 (23): 10467–71. PMID 7479821. 
  • Katsanis N, Fisher EM (1998). "A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3.". Genomics 47 (2): 294–9. doi:10.1006/geno.1997.5115. PMID 9479502. 
  • Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMID 9724649. 
  • Sewalt RG, Gunster MJ, van der Vlag J, et al. (1999). "C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins.". Mol. Cell. Biol. 19 (1): 777–87. PMID 9858600. 
  • Holmes M, Turner J, Fox A, et al. (1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation.". J. Biol. Chem. 274 (33): 23491–8. PMID 10438528. 
  • Furusawa T, Moribe H, Kondoh H, Higashi Y (2000). "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1.". Mol. Cell. Biol. 19 (12): 8581–90. PMID 10567582. 
  • van Vliet J, Turner J, Crossley M (2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription.". Nucleic Acids Res. 28 (9): 1955–62. PMID 10756197. 
  • Yu X, Baer R (2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor.". J. Biol. Chem. 275 (24): 18541–9. doi:10.1074/jbc.M909494199. PMID 10764811. 
  • Schmitz F, Königstorfer A, Südhof TC (2001). "RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function.". Neuron 28 (3): 857–72. PMID 11163272. 
  • Murakami A, Ishida S, Thurlow J, et al. (2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter.". Nucleic Acids Res. 29 (16): 3347–55. PMID 11504872. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Turner J, Nicholas H, Bishop D, et al. (2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2.". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451. 
  • Valenta T, Lukas J, Korinek V (2003). "HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells.". Nucleic Acids Res. 31 (9): 2369–80. PMID 12711682. 
  • Mirnezami AH, Campbell SJ, Darley M, et al. (2004). "Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription.". Curr. Biol. 13 (14): 1234–9. PMID 12867035. 
  • Castet A, Boulahtouf A, Versini G, et al. (2004). "Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition.". Nucleic Acids Res. 32 (6): 1957–66. doi:10.1093/nar/gkh524. PMID 15060175. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Alpatov R, Munguba GC, Caton P, et al. (2005). "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.". Mol. Cell. Biol. 24 (23): 10223–35. doi:10.1128/MCB.24.23.10223-10235.2004. PMID 15542832. 
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