CTBP1

From Wikipedia, the free encyclopedia

C-terminal binding protein 1

PDB rendering based on 1hku.

Available structures: 1hku, 1hl3, 1mx3, 2hu2

Identifiers

Symbol(s)

CTBP1; BARS; MGC104684

External IDs

OMIM: 602618 MGI: 1201685 HomoloGene: 1015

Gene ontology
Molecular Function:	• protein C-terminus binding • transcription factor binding • oxidoreductase activity • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • NAD binding
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation • L-serine biosynthetic process • metabolic process • negative regulation of cell proliferation • viral genome replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001012614 (mRNA)
NP_001012632 (protein)

XM_990134 (mRNA)
XP_995228 (protein)

Location

Chr 4: 1.2 - 1.23 Mb

Chr 5: 33.56 - 33.59 Mb

Pubmed search

[1]

[2]

C-terminal binding protein 1, also known as CTBP1, is a human gene.

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.^[1]

[edit] References

^ Entrez Gene: CTBP1 C-terminal binding protein 1.

[edit] Further reading

Chinnadurai G (2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis.". Mol. Cell 9 (2): 213–24. PMID 11864595.
Schaeper U, Boyd JM, Verma S, et al. (1995). "Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.". Proc. Natl. Acad. Sci. U.S.A. 92 (23): 10467–71. PMID 7479821.
Boyd JM, Subramanian T, Schaeper U, et al. (1993). "A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.". EMBO J. 12 (2): 469–78. PMID 8440238.
Katsanis N, Fisher EM (1998). "A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3.". Genomics 47 (2): 294–9. doi:10.1006/geno.1997.5115. PMID 9479502.
Schaeper U, Subramanian T, Lim L, et al. (1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif.". J. Biol. Chem. 273 (15): 8549–52. PMID 9535825.
Sundqvist A, Sollerbrant K, Svensson C (1998). "The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex.". FEBS Lett. 429 (2): 183–8. PMID 9650586.
Fuks F, Milner J, Kouzarides T (1998). "BRCA2 associates with acetyltransferase activity when bound to P/CAF.". Oncogene 17 (19): 2531–4. doi:10.1038/sj.onc.1202475. PMID 9824164.
Sewalt RG, Gunster MJ, van der Vlag J, et al. (1999). "C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins.". Mol. Cell. Biol. 19 (1): 777–87. PMID 9858600.
Li S, Chen PL, Subramanian T, et al. (1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage.". J. Biol. Chem. 274 (16): 11334–8. PMID 10196224.
Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8. PMID 10359772.
Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B (1999). "Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation.". EMBO J. 18 (12): 3392–403. doi:10.1093/emboj/18.12.3392. PMID 10369679.
Holmes M, Turner J, Fox A, et al. (1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation.". J. Biol. Chem. 274 (33): 23491–8. PMID 10438528.
Furusawa T, Moribe H, Kondoh H, Higashi Y (2000). "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1.". Mol. Cell. Biol. 19 (12): 8581–90. PMID 10567582.
Yu X, Baer R (2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor.". J. Biol. Chem. 275 (24): 18541–9. doi:10.1074/jbc.M909494199. PMID 10764811.
Koipally J, Georgopoulos K (2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.". J. Biol. Chem. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID 10766745.
Melhuish TA, Wotton D (2001). "The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF.". J. Biol. Chem. 275 (50): 39762–6. doi:10.1074/jbc.C000416200. PMID 10995736.
Zhang CL, McKinsey TA, Lu JR, Olson EN (2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.". J. Biol. Chem. 276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID 11022042.
Izutsu K, Kurokawa M, Imai Y, et al. (2001). "The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling.". Blood 97 (9): 2815–22. PMID 11313276.
Palmer S, Brouillet JP, Kilbey A, et al. (2001). "Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins.". J. Biol. Chem. 276 (28): 25834–40. doi:10.1074/jbc.M102343200. PMID 11328817.
Schuierer M, Hilger-Eversheim K, Dobner T, et al. (2001). "Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1.". J. Biol. Chem. 276 (30): 27944–9. doi:10.1074/jbc.M100070200. PMID 11373277.