CSTL1

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Cystatin-like 1
Identifiers
Symbol(s) CSTL1; RCET11; dJ322G13.4
External IDs MGI: 2652834 HomoloGene: 16283
Orthologs
Human Mouse
Entrez 128817 228756
Ensembl ENSG00000125823 ENSMUSG00000055177
Uniprot Q9H114 n/a
Refseq NM_138283 (mRNA)
NP_612140 (protein)		 NM_001004764 (mRNA)
NP_001004764 (protein)
Location Chr 20: 23.37 - 23.37 Mb Chr 2: 148.44 - 148.45 Mb
Pubmed search [1] [2]

Cystatin-like 1, also known as CSTL1, is a human gene.[1]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located at the telomeric end of the cystatin locus and encodes a type 2 cystatin-like protein. The specific function of this protein has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: CSTL1 cystatin-like 1.

[edit] Further reading

  • Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution.". Protein Sci. 6 (1): 5-12. PMID 9007972. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20.". DNA Cell Biol. 13 (2): 97-116. PMID 8179826. 
  • Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2.". Genomics 24 (1): 172-5. doi:10.1006/geno.1994.1595. PMID 7896273. 
  • Dickinson DP, Thiesse M, Dempsey LD, Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes.". Crit. Rev. Oral Biol. Med. 4 (3-4): 573-80. PMID 7690606. 
  • Saitoh E, Isemura S, Sanada K, et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.". Biol. Chem. Hoppe-Seyler 369 Suppl: 191-7. PMID 3202964. 
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