CSTF1

From Wikipedia, the free encyclopedia

Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa

Identifiers

CSTF1; CstF-50; CstFp50

External IDs

OMIM: 600369 MGI: 1914587 HomoloGene: 1012

Gene ontology
Molecular Function:	• RNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• mRNA polyadenylation • mRNA cleavage

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001033521 (mRNA)
NP_001028693 (protein)

NM_024199 (mRNA)
NP_077161 (protein)

Location

Chr 20: 54.4 - 54.41 Mb

Chr 2: 172.06 - 172.07 Mb

Pubmed search

[1]

[2]

Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa, also known as CSTF1, is a human gene.^[1]

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa.

[edit] Further reading

Takagaki Y, Manley JL (1992). "A human polyadenylation factor is a G protein beta-subunit homologue.". J. Biol. Chem. 267 (33): 23471–4. PMID 1358884.
Takagaki Y, MacDonald CC, Shenk T, Manley JL (1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1403–7. PMID 1741396.
Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation.". Genes Dev. 9 (21): 2672–83. PMID 7590244.
Takagaki Y, Manley JL (1994). "A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein.". Nature 372 (6505): 471–4. doi:10.1038/372471a0. PMID 7984242.
Rüegsegger U, Beyer K, Keller W (1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors.". J. Biol. Chem. 271 (11): 6107–13. PMID 8626397.
Kleiman FE, Manley JL (1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.". Science 285 (5433): 1576–9. PMID 10477523.
Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component.". Mol. Cell. Biol. 20 (5): 1515–25. PMID 10669729.
Kleiman FE, Manley JL (2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression.". Cell 104 (5): 743–53. PMID 11257228.
Fong N, Bentley DL (2001). "Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD.". Genes Dev. 15 (14): 1783–95. doi:10.1101/gad.889101. PMID 11459828.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Tsuzuki M, Wu W, Nishikawa H, et al. (2006). "A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats.". Cancer Lett. 233 (1): 108–16. doi:10.1016/j.canlet.2005.03.012. PMID 15878232.