CSRP2

From Wikipedia, the free encyclopedia


Cysteine and glycine-rich protein 2
PDB rendering based on 1a7i.
Available structures: 1a7i, 1cxx, 1ibi, 1qli
Identifiers
Symbol(s) CSRP2; CRP2; LMO5; SmLIM
External IDs OMIM: 601871 MGI1202907 HomoloGene81686
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 1466 13008
Ensembl ENSG00000175183 ENSMUSG00000020186
Uniprot Q16527 Q6QMT3
Refseq NM_001321 (mRNA)
NP_001312 (protein)
NM_007792 (mRNA)
NP_031818 (protein)
Location Chr 12: 75.78 - 75.8 Mb Chr 10: 110.32 - 110.34 Mb
Pubmed search [1] [2]

Cysteine and glycine-rich protein 2, also known as CSRP2, is a human gene.[1]

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.[1]

[edit] References

[edit] Further reading

  • Weiskirchen R, Pino JD, Macalma T, et al. (1996). "The cysteine-rich protein family of highly related LIM domain proteins.". J. Biol. Chem. 270 (48): 28946–54. PMID 7499425. 
  • Jain MK, Fujita KP, Hsieh CM, et al. (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells.". J. Biol. Chem. 271 (17): 10194–9. PMID 8626582. 
  • Karim MA, Ohta K, Egashira M, et al. (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3.". Genomics 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798. 
  • Weiskirchen R, Erdel M, Utermann G, Bister K (1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2.". Genomics 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703. 
  • Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP).". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID 10924333. 
  • Weiskirchen R, Moser M, Weiskirchen S, et al. (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1.". Biochem. J. 359 (Pt 3): 485–96. PMID 11672422. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines.". Cancer Biol. Ther. 1 (5): 556–63. PMID 12496489. 
  • Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines.". Mol. Cancer Res. 1 (9): 631–42. PMID 12861049. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.