CSPG4

From Wikipedia, the free encyclopedia

Chondroitin sulfate proteoglycan 4

Identifiers

CSPG4; MSK16; HMW-MAA; MCSP; MCSPG; MEL-CSPG; NG2

External IDs

OMIM: 601172 MGI: 2153093 HomoloGene: 20445

Gene ontology
Molecular Function:	• signal transducer activity • receptor signaling protein tyrosine phosphatase signaling protein activity • protein binding • receptor signaling protein tyrosine kinase signaling protein activity
Cellular Component:	• proteinaceous extracellular matrix • integral to plasma membrane • cell surface • membrane
Biological Process:	• angiogenesis • cell motility • signal transduction • multicellular organismal development • tissue development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001897 (mRNA)
NP_001888 (protein)

NM_139001 (mRNA)
NP_620570 (protein)

Location

Chr 15: 73.75 - 73.79 Mb

Chr 9: 56.66 - 56.7 Mb

Pubmed search

[1]

[2]

Chondroitin sulfate proteoglycan 4, also known as CSPG4, is a human gene.^[1]

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.^[1]

[edit] References

^ ^a ^b Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4.

[edit] Further reading

Pluschke G, Vanek M, Evans A, et al. (1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan.". Proc. Natl. Acad. Sci. U.S.A. 93 (18): 9710–5. PMID 8790396.
Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R (1997). "Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1.". J. Immunol. 158 (3): 1324–31. PMID 9013976.
Iida J, Meijne AM, Oegema TR, et al. (1998). "A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion.". J. Biol. Chem. 273 (10): 5955–62. PMID 9488735.
Eisenmann KM, McCarthy JB, Simpson MA, et al. (2000). "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.". Nat. Cell Biol. 1 (8): 507–13. doi:10.1038/70302. PMID 10587647.
Barritt DS, Pearn MT, Zisch AH, et al. (2000). "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2.". J. Cell. Biochem. 79 (2): 213–24. PMID 10967549.
Iida J, Pei D, Kang T, et al. (2001). "Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen.". J. Biol. Chem. 276 (22): 18786–94. doi:10.1074/jbc.M010053200. PMID 11278606.
Staub E, Hinzmann B, Rosenthal A (2002). "A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family.". FEBS Lett. 527 (1-3): 114–8. PMID 12220645.
Stegmüller J, Werner H, Nave KA, Trotter J (2003). "The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling.". J. Biol. Chem. 278 (6): 3590–8. doi:10.1074/jbc.M210010200. PMID 12458226.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Legg J, Jensen UB, Broad S, et al. (2004). "Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis.". Development 130 (24): 6049–63. doi:10.1242/dev.00837. PMID 14573520.
Ghali L, Wong ST, Tidman N, et al. (2004). "Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein.". J. Invest. Dermatol. 122 (2): 433–42. doi:10.1046/j.0022-202X.2004.22207.x. PMID 15009727.
Fukushi J, Makagiansar IT, Stallcup WB (2005). "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.". Mol. Biol. Cell 15 (8): 3580–90. doi:10.1091/mbc.E04-03-0236. PMID 15181153.
Yang J, Price MA, Neudauer CL, et al. (2004). "Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms.". J. Cell Biol. 165 (6): 881–91. doi:10.1083/jcb.200403174. PMID 15210734.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Makagiansar IT, Williams S, Dahlin-Huppe K, et al. (2005). "Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility.". J. Biol. Chem. 279 (53): 55262–70. doi:10.1074/jbc.M411045200. PMID 15504744.
Petrini S, Tessa A, Stallcup WB, et al. (2006). "Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency.". Mol. Cell. Neurosci. 30 (3): 408–17. doi:10.1016/j.mcn.2005.08.005. PMID 16169245.
Brekke C, Lundervold A, Enger PØ, et al. (2006). "NG2 expression regulates vascular morphology and function in human brain tumours.". Neuroimage 29 (3): 965–76. doi:10.1016/j.neuroimage.2005.08.026. PMID 16253523.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Luo W, Wang X, Kageshita T, et al. (2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells.". Oncogene 25 (20): 2873–84. doi:10.1038/sj.onc.1209319. PMID 16407841.