CSNK2B

From Wikipedia, the free encyclopedia

Casein kinase 2, beta polypeptide

PDB rendering based on 1jwh.

Available structures: 1jwh, 1qf8, 1rqf

Identifiers

Symbol(s)

CSNK2B; CK2B; CK2N; CSK2B; G5A; MGC138222; MGC138224

External IDs

OMIM: 115441 MGI: 88548 HomoloGene: 55572

Gene ontology
Molecular Function:	• protein kinase CK2 activity • protein kinase CK2 regulator activity • kinase activity • identical protein binding
Cellular Component:	• protein kinase CK2 complex
Biological Process:	• signal transduction • Wnt receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001320 (mRNA)
NP_001311 (protein)

NM_009975 (mRNA)
NP_034105 (protein)

Location

Chr c6_COX: 31.77 - 31.78 Mb

Chr 17: 34.72 - 34.73 Mb

Pubmed search

[1]

[2]

Casein kinase 2, beta polypeptide, also known as CSNK2B, is a human gene.

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.^[1]

[edit] References

^ Entrez Gene: CSNK2B casein kinase 2, beta polypeptide.

[edit] Further reading

Schubert U, Schneider T, Henklein P, et al. (1992). "Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II.". Eur. J. Biochem. 204 (2): 875–83. PMID 1541298.
Teitz T, Eli D, Penner M, et al. (1990). "Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells.". Mutat. Res. 236 (1): 85–97. PMID 1694965.
Voss H, Wirkner U, Jakobi R, et al. (1991). "Structure of the gene encoding human casein kinase II subunit beta.". J. Biol. Chem. 266 (21): 13706–11. PMID 1856204.
Litchfield DW, Lozeman FJ, Cicirelli MF, et al. (1991). "Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.". J. Biol. Chem. 266 (30): 20380–9. PMID 1939094.
Yang-Feng TL, Teitz T, Cheung MC, et al. (1991). "Assignment of the human casein kinase II beta-subunit gene to 6p12----p21.". Genomics 8 (4): 741–2. PMID 2276748.
Ackerman P, Glover CV, Osheroff N (1990). "Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 821–5. PMID 2300566.
Heller-Harrison RA, Meisner H, Czech MP (1990). "Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.". Biochemistry 28 (23): 9053–8. PMID 2513884.
Jakobi R, Voss H, Pyerin W (1989). "Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta.". Eur. J. Biochem. 183 (1): 227–33. PMID 2666134.
Vincent MJ, Abdul Jabbar M (1996). "The human immunodeficiency virus type 1 Vpu protein: a potential regulator of proteolysis and protein transport in the mammalian secretory pathway.". Virology 213 (2): 639–49. PMID 7491787.
Litchfield DW, Bosc DG, Slominski E (1995). "The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2.". Biochim. Biophys. Acta 1269 (1): 69–78. PMID 7578274.
Jin YJ, Burakoff SJ (1993). "The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin.". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7769–73. PMID 7689229.
Gietz RD, Graham KC, Litchfield DW (1995). "Interactions between the subunits of casein kinase II.". J. Biol. Chem. 270 (22): 13017–21. PMID 7768894.
Szebeni A, Herrera JE, Olson MO (1995). "Interaction of nucleolar protein B23 with peptides related to nuclear localization signals.". Biochemistry 34 (25): 8037–42. PMID 7794916.
Arnold SF, Obourn JD, Jaffe H, Notides AC (1995). "Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.". Mol. Endocrinol. 8 (9): 1208–14. PMID 7838153.
Pyerin W (1994). "Human casein kinase II: structures, genes, expression and requirement in cell growth stimulation.". Adv. Enzyme Regul. 34: 225–46. PMID 7942276.
el Benna J, Faust LP, Babior BM (1994). "The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.". J. Biol. Chem. 269 (38): 23431–6. PMID 8089108.
Schubert U, Henklein P, Boldyreff B, et al. (1994). "The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif.". J. Mol. Biol. 236 (1): 16–25. doi:10.1006/jmbi.1994.1114. PMID 8107101.
Schubert U, Strebel K (1994). "Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments.". J. Virol. 68 (4): 2260–71. PMID 8139011.
Tanasijevic MJ, Myers MG, Thoma RS, et al. (1993). "Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.". J. Biol. Chem. 268 (24): 18157–66. PMID 8349691.
Friborg J, Ladha A, Göttlinger H, et al. (1996). "Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 8 (1): 10–22. PMID 8548340.