CSNK2A1

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See also: Casein kinase 2

Casein kinase 2, alpha 1 polypeptide
PDB rendering based on 1jwh.
Available structures: 1jwh, 1na7, 1pjk, 1ymi
Identifiers
Symbol(s)	CSNK2A1; CK2A1; CKII; CKII alpha
External IDs	OMIM: 115440 MGI: 88543 HomoloGene: 1429
Gene ontology Molecular Function: • nucleotide binding • protein serine/threonine kinase activity • protein kinase CK2 activity • protein binding • ATP binding • transferase activity Cellular Component: • nucleus • plasma membrane Biological Process: • protein amino acid phosphorylation • signal transduction • Wnt receptor signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1457	12995
Ensembl	ENSG00000101266	ENSMUSG00000057808
Uniprot	P68400	Q61177
Refseq	NM_001895 (mRNA) NP_001886 (protein)	NM_007788 (mRNA) NP_031814 (protein)
Location	Chr 20: 0.41 - 0.47 Mb	Chr 1: 158.36 - 158.36 Mb
Pubmed search	[1]	[2]

Casein kinase 2, alpha 1 polypeptide, also known as CSNK2A1, is a human gene.

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.^[1]

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