CRSP3

From Wikipedia, the free encyclopedia

Cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa

Identifiers

CRSP3; CRSP130; CRSP133; DKFZp434H0117; DRIP130; MED23; SUR2

External IDs

OMIM: 605042 MGI: 1917458 HomoloGene: 3552

Gene ontology
Molecular Function:	• transcription coactivator activity • receptor activity • transcription regulator activity
Cellular Component:	• transcription factor complex
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004830 (mRNA)
NP_004821 (protein)

NM_027347 (mRNA)
NP_081623 (protein)

Location

Chr 6: 131.94 - 131.99 Mb

Chr 10: 24.56 - 24.6 Mb

Pubmed search

[1]

[2]

Cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa, also known as CRSP3, is a human gene.^[1]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CRSP3 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa.

[edit] Further reading

Ryu S, Zhou S, Ladurner AG, Tjian R (1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.". Nature 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.
Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
Boyer TG, Martin ME, Lees E, et al. (1999). "Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein.". Nature 399 (6733): 276–9. doi:10.1038/20466. PMID 10353252.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462.
Ko L, Cardona GR, Chin WW (2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. PMID 10823961.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Stevens JL, Cantin GT, Wang G, et al. (2002). "Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit.". Science 296 (5568): 755–8. doi:10.1126/science.1068943. PMID 11934987.
Asada S, Choi Y, Yamada M, et al. (2002). "External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12747–52. doi:10.1073/pnas.202162199. PMID 12242338.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Goldberg SF, Miele ME, Hatta N, et al. (2003). "Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP.". Cancer Res. 63 (2): 432–40. PMID 12543799.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Mo X, Kowenz-Leutz E, Xu H, Leutz A (2004). "Ras induces mediator complex exchange on C/EBP beta.". Mol. Cell 13 (2): 241–50. PMID 14759369.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Wada O, Oishi H, Takada I, et al. (2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220.". Oncogene 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.