Crotonoyl-(acyl-carrier-protein) hydratase

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In enzymology, a crotonoyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58) is an enzyme that catalyzes the chemical reaction

(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] $\rightleftharpoons$ but-2-enoyl-[acyl-carrier-protein] + H₂O

Hence, this enzyme has one substrate, [[(3R)-3-hydroxybutanoyl-[acyl-carrier-protein]]], and two products, [[but-2-enoyl-[acyl-carrier-protein]]] and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase (but-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase, beta-hydroxybutyryl acyl carrier protein dehydrase, beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase, beta-hydroxybutyryl acyl carrier protein dehydrase, enoyl acyl carrier protein hydrase, crotonyl acyl carrier protein hydratase, 3-hydroxybutyryl acyl carrier protein dehydratase, beta-hydroxybutyryl acyl carrier, and protein dehydrase. This enzyme participates in fatty acid biosynthesis.

[edit] References

IUBMB entry for 4.2.1.58
BRENDA references for 4.2.1.58 (Recommended.)
PubMed references for 4.2.1.58
PubMed Central references for 4.2.1.58
Google Scholar references for 4.2.1.58
MAJERUS PW, ALBERTS AW, VAGELOS PR (1965). "ACYL CARRIER PROTEIN. 3. AN ENOYL HYDRASE SPECIFIC FOR ACYL CARRIER PROTEIN THIOESTERS". J. Biol. Chem. 240: 618–21. PMID 14275113.
Mizugaki M, Weeks G, Toomey RE, Wakil SJ (1968). "Studies on the mechanism of fatty acid synthesis. XX. Preparation and general properties of beta-hydroxybutyryl acyl carrier protein dehydrase". J. Biol. Chem. 243: 3661–70. PMID 5658542.