CROP (gene)

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Cisplatin resistance-associated overexpressed protein
Identifiers
Symbol(s) CROP; LUC7A; OA48-18
External IDs OMIM: 609434 MGI: 1914934 HomoloGene: 75056
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51747 67684
Ensembl ENSG00000108848 ENSMUSG00000020863
Uniprot O95232 Q5SUF2
Refseq NM_006107 (mRNA)
NP_006098 (protein)		 NM_026313 (mRNA)
NP_080589 (protein)
Location Chr 17: 46.15 - 46.19 Mb Chr 11: 94.11 - 94.14 Mb
Pubmed search [1] [2]

Cisplatin resistance-associated overexpressed protein, also known as CROP, is a human gene.[1]

This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: CROP cisplatin resistance-associated overexpressed protein.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Nishii Y, Morishima M, Kakehi Y, et al. (2000). "CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line.". FEBS Lett. 465 (2-3): 153–6. PMID 10631324. 
  • Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells.". J. Biomed. Sci. 7 (2): 152–9. PMID 10754390. 
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Umehara H, Nishii Y, Morishima M, et al. (2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A.". Biochem. Biophys. Res. Commun. 301 (2): 324–9. PMID 12565863. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains.". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMID 16482509. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Puig O, Bragado-Nilsson E, Koski T, Séraphin B (2007). "The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human.". Nucleic Acids Res. 35 (17): 5874–85. doi:10.1093/nar/gkm505. PMID 17726058. 
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