CRLF2

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Cytokine receptor-like factor 2
Identifiers
Symbol(s) CRLF2; CRL2; CRLF2Y; TSLPR
External IDs OMIM: 300357 MGI: 1889506 HomoloGene: 49476
Orthologs
Human Mouse
Entrez 64109 57914
Ensembl n/a ENSMUSG00000033467
Uniprot n/a Q05DC7
Refseq XM_001133960 (mRNA)
XP_001133960 (protein)		 XM_001005641 (mRNA)
XP_001005641 (protein)
Location n/a Chr 5: 109.8 - 109.8 Mb
Pubmed search [1] [2]

Cytokine receptor-like factor 2, also known as CRLF2, is a human gene.[1]

Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: CRLF2 cytokine receptor-like factor 2.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Hiroyama T, Iwama A, Morita Y, et al. (2000). "Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells.". Biochem. Biophys. Res. Commun. 272 (1): 224–9. doi:10.1006/bbrc.2000.2764. PMID 10872831. 
  • Zhang W, Wang J, Wang Q, et al. (2001). "Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes.". Biochem. Biophys. Res. Commun. 281 (4): 878–83. doi:10.1006/bbrc.2001.4432. PMID 11237741. 
  • Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.". J. Immunol. 167 (1): 336–43. PMID 11418668. 
  • Tonozuka Y, Fujio K, Sugiyama T, et al. (2001). "Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR.". Cytogenet. Cell Genet. 93 (1-2): 23–5. PMID 11474172. 
  • Blagoev B, Nielsen MM, Angrist M, et al. (2002). "Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene.". Gene 284 (1-2): 161–8. PMID 11891057. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Rochman I, Watanabe N, Arima K, et al. (2007). "Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells.". J. Immunol. 178 (11): 6720–4. PMID 17513717. 
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