CRLF1

From Wikipedia, the free encyclopedia

Cytokine receptor-like factor 1

Identifiers

CRLF1; CISS; CISS1; CLF; CLF-1; NR6

External IDs

OMIM: 604237 MGI: 1340030 HomoloGene: 3489

Gene ontology
Molecular Function:	• receptor activity • cytokine binding
Cellular Component:	• extracellular space
Biological Process:	• antimicrobial humoral response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004750 (mRNA)
NP_004741 (protein)

XM_001005787 (mRNA)
XP_001005787 (protein)

Location

Chr 19: 18.57 - 18.58 Mb

Chr 8: 73.42 - 73.43 Mb

Pubmed search

[1]

[2]

Cytokine receptor-like factor 1, also known as CRLF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: CRLF1 cytokine receptor-like factor 1.

[edit] Further reading

Elson GC, Graber P, Losberger C, et al. (1998). "Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family.". J. Immunol. 161 (3): 1371-9. PMID 9686600.
Elson GC, Lelièvre E, Guillet C, et al. (2000). "CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.". Nat. Neurosci. 3 (9): 867-72. doi:10.1038/78765. PMID 10966616.
Lelièvre E, Plun-Favreau H, Chevalier S, et al. (2001). "Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component.". J. Biol. Chem. 276 (25): 22476-84. doi:10.1074/jbc.M101681200. PMID 11294841.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Knappskog PM, Majewski J, Livneh A, et al. (2003). "Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene.". Am. J. Hum. Genet. 72 (2): 375-83. PMID 12509788.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Heese K, Yamada T, Akatsu H, et al. (2005). "Characterizing the new transcription regulator protein p60TRP.". J. Cell. Biochem. 91 (5): 1030-42. doi:10.1002/jcb.20010. PMID 15034937.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Dagoneau N, Bellais S, Blanchet P, et al. (2007). "Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes.". Am. J. Hum. Genet. 80 (5): 966-70. doi:10.1086/513608. PMID 17436251.
Crisponi L, Crisponi G, Meloni A, et al. (2007). "Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1.". Am. J. Hum. Genet. 80 (5): 971-81. doi:10.1086/516843. PMID 17436252.