CRISP1

From Wikipedia, the free encyclopedia

Cysteine-rich secretory protein 1

Identifiers

CRISP1; AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP

External IDs

OMIM: 601193 MGI: 1925331 HomoloGene: 81683

Gene ontology
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• spermatogenesis • fusion of sperm to egg plasma membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001131 (mRNA)
NP_001122 (protein)

NM_030033 (mRNA)
NP_084309 (protein)

Location

Chr 6: 49.91 - 49.95 Mb

Chr 1: 18.1 - 18.13 Mb

Pubmed search

[1]

[2]

Cysteine-rich secretory protein 1, also known as CRISP1, is a human gene.^[1]

Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. This protein is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head where it plays a role at fertilization in sperm-egg fusion through complementary sites localized on the egg surface. Two isoforms are encoded by transcript variants of this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CRISP1 cysteine-rich secretory protein 1.

[edit] Further reading

Kirchhoff C (1998). "Molecular characterization of epididymal proteins.". Rev. Reprod. 3 (2): 86–95. PMID 9685187.
Cuasnicú PS, Ellerman DA, Cohen DJ, et al. (2002). "Molecular mechanisms involved in mammalian gamete fusion.". Arch. Med. Res. 32 (6): 614–8. PMID 11750738.
Evans JP (2003). "The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization.". Hum. Reprod. Update 8 (4): 297–311. PMID 12206465.
Hayashi M (1996). "[Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization]". Hokkaido Igaku Zasshi 70 (5): 743–53. PMID 8543280.
Krätzschmar J, Haendler B, Eberspaecher U, et al. (1996). "The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.". Eur. J. Biochem. 236 (3): 827–36. PMID 8665901.
Hayashi M, Fujimoto S, Takano H, et al. (1997). "Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1).". Genomics 32 (3): 367–74. doi:10.1006/geno.1996.0131. PMID 8838800.
Cohen DJ, Ellerman DA, Busso D, et al. (2001). "Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg.". Biol. Reprod. 65 (4): 1000–5. PMID 11566719.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.