Talk:Cre-Lox recombination
From Wikipedia, the free encyclopedia
 |
This article is part of WikiProject Genetics, an attempt to build a comprehensive and detailed guide to genetics on Wikipedia. If you would like to participate, you can edit this page, or visit the project page to join the project and/or contribute to the discussion. |
| ??? | This article has not yet received a rating on the quality scale. |
| ??? | This article has not yet received an importance rating. |
 |
This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Restriction enzyme. |
||
| Start | This article has been rated as start-Class on the assessment scale. |
||
| Low | This article is on a subject of low-importance within molecular and cellular biology. | ||
|
Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need. |
|||
The original article was deleted and replaced with a cut and paste from the following article. http://bioteach.ubc.ca/MolecularBiology/TargetingYourDNAWithTheCreloxSystem/
Not only is this article not very well written it is plagarism. I vote we revert back to the previous article. While that also had many flaws it was not that bad and certainly no worse than this current one. David D. (Talk) 22:33, 2 July 2006 (UTC)
- OK i reverted back to original. Yes it needs work, but it appears not to be plagarism. David D. (Talk) 22:42, 2 July 2006 (UTC)
-
- Anyone want to reference this? Dr Aaron 13:24, 6 December 2006 (UTC)
Contents |
[edit] This article is not plagiarised
The language in the original article was not plagiarised. Thank you David, I admit I had consulted the website provided above, but i also consulted various undergrad level molecular biology/biochemistry text books. I have presented a seminar on this topic and i am open to any criticism regarding the factual correctness of the article. —Preceding unsigned comment added by M murty (talk • contribs)
- Hi Murty, welcome back. The plagiarism comment was not directed at your version, and in fact it was your version i reverted back to. The plagiarism edit was from Ladeer (talk · contribs). If you look in the history you will find this edit is a direct copy and paste from the article cited above. David D. (Talk) 15:34, 13 March 2007 (UTC)
[edit] References needed
I think some references for this article would be appropriate. I found a brief paragraph in Molecular Cell Biology by Alberts (2002) in Chapter 8, in the section titled "Studying Gene Expression and Function". Unfortunately I was using the NIH online version of the book which has no page numbers available, so if someone owns a copy of the book perhaps they could add that reference on.Thoimis 06:56, 21 March 2007 (UTC)
i apologise for the misunderstanding. thx for reverting back to the original. M murty 09:48, 22 March 2007 (UTC)
[edit] Site-specific recombination: a suggestion
There's an overview of site-specific recombination in this article. Obviously it's fine to gloss what SSR is briefly, but wouldn't it make better sense to reference the existing article on this topic rather than duplicate that information here? I don't want to molest the article myself, as clearly a lot of careful work has gone into it! SamTheCentipede 22:41, 26 June 2007 (UTC)
[edit] Article isnt bad, but isnt great either
Imo this article includes too much useless / pseudoinformation ("Tt is a quick an efficient process."), whilst glossing over the main point of the cre/loxp system in a couple of unclear sentences. The 8p spacer sequence has been mentioned to either cause inversions or deletions depending on its orientation, but this needs to be explained in more detail ideally. The whole point of the system is that the 8bp spacers orientation are dependant on the orientation of another loxp site : if the sequences run the same way, it will create a deletion, if they run opposite in reference to another one, it will create an inversion.
Its good that the article mentioned this point to begin with, as most sources skip this out all together. But with relevance to cre-lox recombination, its one of the most important features, and deserves more than a sentance or two. Pherhaps some diagrams? —Preceding unsigned comment added by 130.88.91.224 (talk) 12:45, 11 February 2008 (UTC)
- Agreed. Additionally I'm a little confused as to why much of the article is devoted to descriptions of homologous and site-specific recombination. These already have their own articles, so only a very brief description should be necessary. I don't know whether any more technical stuff would be useful to the article regarding the reaction mechanism itself and the topology of reaction products... it may go a bit beyond the scope of an encyclopedia article. Let me know if I can help. Blackmetalbaz (talk) 11:33, 10 April 2008 (UTC)
