Creatinine deaminase

From Wikipedia, the free encyclopedia

In enzymology, a creatinine deaminase (EC 3.5.4.21) is an enzyme that catalyzes the chemical reaction

creatinine + H₂O N-methylhydantoin + NH₃

Thus, the two substrates of this enzyme are creatinine and H₂O, whereas its two products are N-methylhydantoin and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is creatinine iminohydrolase. Other names in common use include creatinine hydrolase, and creatinine desiminase. This enzyme participates in arginine and proline metabolism.

[edit] References

• IUBMB entry for 3.5.4.21
• BRENDA references for 3.5.4.21 (Recommended.)
• PubMed references for 3.5.4.21
• PubMed Central references for 3.5.4.21
• Google Scholar references for 3.5.4.21
• Szulmajster J (1958). "Bacterial degradation of creatinine. II. Creatinine desimidase". Biochim. Biophys. Acta 30: 154–163. doi:10.1016/0006-3002(58)90252-X. 

[edit] External links

The CAS registry number for this enzyme class is 37289-15-9.

• IUBMB entry for 3.5.4.21

• KEGG entry for 3.5.4.21

• BRENDA entry for 3.5.4.21

• NiceZyme view of 3.5.4.21

• EC2PDB: PDB structures for 3.5.4.21

• PRIAM entry for 3.5.4.21

• PUMA2 entry for 3.5.4.21

• IntEnz: Integrated Enzyme entry for 3.5.4.21

• MetaCyc entry for 3.5.4.21

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047790: creatinine deaminase

• AMIGO entry for GO code 0047790: creatinine deaminase