Creatininase

From Wikipedia, the free encyclopedia

In enzymology, a creatininase (EC 3.5.2.10) is an enzyme that catalyzes the chemical reaction

creatinine + H₂O creatine

Thus, the two substrates of this enzyme are creatinine and H₂O, whereas its product is creatine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is creatinine amidohydrolase. This enzyme is also called creatinine hydrolase. This enzyme participates in arginine and proline metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1J2T, 1J2U, 1Q3K, and 1V7Z.

[edit] References

• IUBMB entry for 3.5.2.10
• BRENDA references for 3.5.2.10 (Recommended.)
• PubMed references for 3.5.2.10
• PubMed Central references for 3.5.2.10
• Google Scholar references for 3.5.2.10
• Tsuru, D, Oka I and Yoshimoto T (1976). "Creatinine decomposing enzymes in Pseudomonas putida". Agric. Biol. Chem. 40: 1011–1018. 

[edit] External links

The CAS registry number for this enzyme class is 9025-13-2.

• IUBMB entry for 3.5.2.10

• KEGG entry for 3.5.2.10

• BRENDA entry for 3.5.2.10

• NiceZyme view of 3.5.2.10

• EC2PDB: PDB structures for 3.5.2.10

• PRIAM entry for 3.5.2.10

• PUMA2 entry for 3.5.2.10

• IntEnz: Integrated Enzyme entry for 3.5.2.10

• MetaCyc entry for 3.5.2.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047789: creatininase

• AMIGO entry for GO code 0047789: creatininase