Creatinase

From Wikipedia, the free encyclopedia

In enzymology, a creatinase (EC 3.5.3.3) is an enzyme that catalyzes the chemical reaction

creatine + H₂O sarcosine + urea

Thus, the two substrates of this enzyme are creatine and H₂O, whereas its two products are sarcosine and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is creatine amidinohydrolase. This enzyme participates in arginine and proline metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1CHM and 1KP0.

[edit] References

• IUBMB entry for 3.5.3.3
• BRENDA references for 3.5.3.3 (Recommended.)
• PubMed references for 3.5.3.3
• PubMed Central references for 3.5.3.3
• Google Scholar references for 3.5.3.3
• ROCHE J, LACOMBE G, GIRARD H (1950). "[On the specificity of certain bacterial deguanidases generating urea and on arginindihydrolase.]". Biochim. Biophys. Acta. 6: 210–6. PMID 14791411. 
• Yoshimoto T, Oka I, Tsuru D (Tokyo). "Purification, crystallization, and some properties of creatine amidinohydrolase from Pseudomonas putida". J. Biochem.: 1381–3. PMID 8443. 

[edit] External links

The CAS registry number for this enzyme class is 37340-58-2.

• IUBMB entry for 3.5.3.3

• KEGG entry for 3.5.3.3

• BRENDA entry for 3.5.3.3

• NiceZyme view of 3.5.3.3

• EC2PDB: PDB structures for 3.5.3.3

• PRIAM entry for 3.5.3.3

• PUMA2 entry for 3.5.3.3

• IntEnz: Integrated Enzyme entry for 3.5.3.3

• MetaCyc entry for 3.5.3.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016980: creatinase

• AMIGO entry for GO code 0016980: creatinase