CREG1

From Wikipedia, the free encyclopedia

Cellular repressor of E1A-stimulated genes 1

PDB rendering based on 1xhn.

Available structures: 1xhn

Identifiers

Symbol(s)

CREG1; CREG

External IDs

MGI: 1344382 HomoloGene: 31199

Gene ontology
Molecular Function:	• RNA polymerase II transcription factor activity • transcription corepressor activity • transcription factor binding
Cellular Component:	• transcription factor complex
Biological Process:	• regulation of cell growth • regulation of transcription from RNA polymerase II promoter • multicellular organismal development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003851 (mRNA)
NP_003842 (protein)

NM_011804 (mRNA)
NP_035934 (protein)

Location

Chr 1: 165.78 - 165.79 Mb

Chr 1: 167.6 - 167.61 Mb

Pubmed search

[1]

[2]

Cellular repressor of E1A-stimulated genes 1, also known as CREG1, is a human gene.^[1]

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.^[1]

[edit] References

^ ^a ^b Entrez Gene: CREG1 cellular repressor of E1A-stimulated genes 1.

[edit] Further reading

Veal E, Eisenstein M, Tseng ZH, Gill G (1998). "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.". Mol. Cell. Biol. 18 (9): 5032–41. PMID 9710587.
Veal E, Groisman R, Eisenstein M, Gill G (2000). "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells.". Oncogene 19 (17): 2120–8. doi:10.1038/sj.onc.1203529. PMID 10815803.
Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.". Hypertens. Res. 25 (4): 647–52. PMID 12358155.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Di Bacco A, Gill G (2003). "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor.". Oncogene 22 (35): 5436–45. doi:10.1038/sj.onc.1206670. PMID 12934103.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Sacher M, Di Bacco A, Lunin VV, et al. (2006). "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation.". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18326–31. doi:10.1073/pnas.0505071102. PMID 16344469.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.